Overview
3-Methylindole, commonly known as skatole, is an organic compound with a distinctive odor that is fecal at high concentrations but floral when highly diluted. It is naturally found in animal feces and certain plants. Industrially, it is synthesized for use in perfumery and as a flavoring agent. The compound is a derivative of indole, featuring a methyl group at the 3-position. Its unique aromatic properties make it valuable in creating complex fragrances and flavors, despite its unpleasant smell in concentrated forms.
Physical and Chemical Properties
3-Methylindole is a white crystalline solid with a molecular weight of 131.18 g/mol. It has a melting point of 95-98°C and a boiling point of 265-266°C. The compound is soluble in organic solvents like ethanol and ether but only slightly soluble in water. Its density is 1.04 g/cm³, and it exhibits strong aromatic characteristics. The odor profile changes significantly with concentration, making it versatile in applications where controlled scent profiles are required.
Main Applications
3-Methylindole is primarily used in the perfume industry, where it contributes to musky and floral notes when highly diluted. It is also employed as a flavoring agent in certain food products, adding a subtle complexity to flavors. In chemical research, 3-methylindole serves as a precursor or intermediate in the synthesis of more complex organic compounds. Its role in studying aromatic systems and heterocyclic chemistry is well-documented.
Safety and Storage
3-Methylindole is classified as harmful if swallowed or inhaled and can cause skin and eye irritation. Proper personal protective equipment (PPE) such as gloves and goggles should be used when handling the compound. Storage should be in a cool, dry place, away from light and moisture to prevent degradation. Containers must be tightly sealed to avoid contamination and evaporation.
B2B Procurement Guide
When procuring 3-methylindole, buyers should prioritize suppliers with certifications such as ISO or GMP to ensure product quality. Purity grades of 98% or higher are typically required for industrial applications. Price ranges vary based on purity and supplier, with bulk purchases often offering cost advantages. Buyers should also consider logistics, such as shipping conditions and lead times, to ensure the compound arrives in optimal condition.
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