Overview
Daphnetin, also known as 7,8-dihydroxycoumarin, is a naturally occurring coumarin derivative found in plants like Daphne odora. It has been used in traditional Chinese medicine for centuries, primarily for its anti-inflammatory and analgesic properties. Modern research has expanded its applications into pharmaceuticals, particularly for treating inflammatory conditions such as rheumatoid arthritis. The compound is valued for its dual functionality as both a therapeutic agent and a research tool. Its ability to modulate inflammatory pathways makes it a subject of ongoing scientific studies, aiming to develop new treatments for chronic inflammatory diseases.
Physical and Chemical Properties
Daphnetin is a light yellow to white crystalline powder with a molecular weight of 178.14 g/mol. It has a melting point of approximately 260-262°C and is soluble in organic solvents like ethanol, methanol, and DMSO, though it is only slightly soluble in water. These properties make it suitable for various pharmaceutical formulations. The compound's structure includes two hydroxyl groups, which contribute to its antioxidant activity. This structural feature also enhances its ability to interact with biological targets, making it effective in reducing oxidative stress and inflammation in cellular models.
Main Applications
Daphnetin is primarily used in the pharmaceutical industry for developing anti-inflammatory and analgesic drugs. Its efficacy in treating rheumatoid arthritis has been demonstrated in both preclinical and clinical studies. Additionally, it is used in traditional Chinese medicine to alleviate pain and reduce inflammation. Beyond therapeutics, daphnetin serves as a valuable compound in biochemical research. Scientists use it to study inflammatory pathways and oxidative stress mechanisms, contributing to the broader understanding of these processes and potential interventions.
Safety and Storage
Daphnetin should be handled with care to avoid inhalation or direct contact with skin and eyes. Personal protective equipment, such as gloves and goggles, is recommended when working with this compound. Proper storage conditions include a cool, dry place away from light and moisture to maintain its stability. In case of accidental exposure, rinse affected areas with plenty of water and seek medical advice if necessary. Safety data sheets (SDS) should be reviewed before use, and all handling should comply with local regulations for chemical safety.
B2B Procurement Guide
When procuring daphnetin for B2B purposes, it is crucial to verify the purity of the compound, typically through HPLC analysis. Suppliers should provide certificates of analysis (CoA) to confirm the product's specifications. Additionally, buyers should assess the supplier's credibility, including their track record and compliance with regulatory standards. Price ranges vary based on purity and quantity, with higher purity grades commanding premium prices. Bulk purchases may offer cost savings, but buyers should ensure that storage and handling protocols are followed to maintain product integrity during transit and storage.
Related Manufacturers
- 主营：钩藤碱、丹皮酚、c17h26o10、祖师麻甲素、高良姜、丹参酮、鞣花酸、川楝素、苍术素、芦竹碱、管花苷、苦参碱、土贝母、柚皮素、白麻苷、甜菜碱、紫草素、络石苷、木皂苷、苏木素、甘露糖、番茄碱、青蒿酸、皂苷rg2、芹菜素、紫杉醇
- 主营：氧化小檗碱、氧化石蒜碱、棉酚、祖师麻甲素、1-脱氧野尻霉素、花椒毒酚、4-去甲基鬼臼毒素、杨芽黄素、圣草酚、秦皮素、瑞香素、五味子酚、甘草素、甘草苷、连翘苷
- 主营：甲基原、钩藤碱、络塞定、丹皮酚、2086-83-1、6836-11-9、鞣花酸、川楝素、黄芩素、苍术素、松脂素、管花苷、熊果酸、苦参碱、6926-08-5、土莫酸、苜蓿素、茯苓酸、柚皮素、3668-14-2、白麻苷、秦皮苷、葛花苷、山奈酚、柚皮苷
- 主营：药品检测标准品、药物杂质标准品、对照品、中药对照药材、中药农残空白基质、分析标准品、仪器检测校准品、金属离子标准溶液、滴定溶液、食品检测标准物质、有机检测标准溶液、指示液、缓冲液、电导率溶液、PH标准溶液、熔点标准品、国家标准物质、比色液
- 主营：标准品、人参皂苷、橙皮油素、祖师麻甲素、芥子碱硫氰酸盐
- 主营：瑞香素祖师麻甲素、白僵菌素、薯蓣皂苷
- 主营：Theasinensin A、Theasinensin B、Theasinensin C、瑞香素祖师麻甲素、花冠木碱、白头翁皂苷D、人参皂苷Ro、矢车菊素-3-半乳糖、竹节参皂苷IVa、林生续断苷I、东当归内酯B、银杏内酯B、欧当归内酯A、70987-96-1、金合欢素、黄芩苷甲酯、樱黄素、台湾泽兰内酯、芫花素、蛇床子素、知母皂苷元、白头翁皂苷B4
- 主营：酒渣碱、异常山乙素、芦丁标准品、祖师麻甲素、对照品标准品
- 主营：桤木酮、香附酮、1617-70-5、皂苷rd2、苍术素、2586-96-1、松脂素、管花苷、dl-醉椒、柯诺辛、苜蓿素、夹竹桃、7729-23-9、5928-25-6、化合物、口山酮、3668-14-2、白麻苷、异甘草、木皂苷、脱氧马、刺五加、皂苷rg3、苷甲酯、2292-16-2
- 主营：芍药素、花姜酮、氨基辛酸、祖师麻甲素、飞燕草素、天竺葵素、矮牵牛素、葡萄糖苷、半乳糖苷、阿拉伯糖苷、天竺葵色素、去氢钩藤碱、氯化锦葵色素
- 主营：对照品、中药多糖、检验检测服务、祖师麻甲素、中药研究服务、CMO/CDMO
- 主营：龙胆苦苷、粉防己碱、獐牙菜苦苷、祖师麻甲素、杨梅苷
- 主营：祖师麻甲素、蛋白质、重组蛋白、细胞
- 主营：桤木酮、淫羊藿、皂苷bii、祖师麻甲素、泽泻醇、香附酮、棕榈碱、羟苯基、半乳糖、山酮iii、甘草酚、侧柏酮、精氨酸、佛尔酮、维生素、管花苷、虫草素、对照品、利卡灵、卵磷脂、大豆苷、姜黄素、黄烷酮、半合成、苹果酸、三羟基
- 主营：前胡醇、甘氨酸、毛喉帖、祖师麻甲素486、水苏糖、金合欢、银椴苷、银杏叶、络塞定、茄边碱、鸡骨草、石蒜碱、广藿香、高良姜、绵子糖、紫苏葶、女贞子、紫苏烯、旋复花、肌氨酸、双黄酮、松脂素、甲乙基、棉花素、褪黑素、鸡骨香