Overview
Zinc L-Histidinate is a chelated mineral complex where zinc is bound to the amino acid L-histidine. This formulation enhances zinc's absorption and bioavailability compared to inorganic zinc salts like zinc oxide or sulfate. It is widely used in nutraceuticals and pharmaceuticals due to its superior metabolic efficiency and minimal gastrointestinal side effects. The compound is particularly favored in dietary supplements targeting immune support, wound healing, and cognitive function. Its stability in various pH conditions makes it suitable for inclusion in liquid and solid formulations. B2B buyers often source it from specialized manufacturers with expertise in amino acid chelation technology.
Physical and Chemical Properties
Zinc L-Histidinate appears as a fine white powder with high water solubility, a critical feature for applications in liquid supplements. The chelation process protects zinc from interactions with other compounds in the digestive tract, ensuring optimal absorption. Its molecular structure includes one zinc ion coordinated with two L-histidine molecules, forming a stable ring complex. Unlike inorganic zinc salts, this compound is non-hygroscopic, reducing clumping during storage. It remains stable under typical processing temperatures (up to 120°C), making it suitable for tablet compression and encapsulation. Analytical methods like HPLC and atomic absorption spectroscopy are used to verify its purity and zinc content.
Main Applications
The primary use of Zinc L-Histidinate is in dietary supplements, especially those designed for immune system support and zinc deficiency correction. Its high bioavailability allows for lower dosages while maintaining efficacy, reducing the risk of gastrointestinal discomfort associated with higher doses of inorganic zinc. In pharmaceuticals, it is incorporated into lozenges for sore throat relief and topical formulations for wound healing. Functional food manufacturers add it to fortified beverages and cereals. Recent research explores its potential in neuroprotective therapies due to zinc's role in synaptic function and histidine's antioxidant properties.
Safety and Storage
Zinc L-Histidinate is classified as generally safe for oral consumption within recommended dosages (typically 15–40 mg elemental zinc per day for adults). Overdose may lead to nausea or copper deficiency with prolonged use. Industrial handlers should use PPE to avoid powder inhalation. Proper storage involves airtight containers in environments below 25°C and <60% relative humidity. Bulk quantities are often packaged in aluminum-lined bags with desiccants. Stability studies indicate a shelf life of at least 24 months under these conditions, though retesting is advised after prolonged storage.
B2B Procurement Guide
When sourcing Zinc L-Histidinate, prioritize suppliers with documented cGMP compliance and batch-specific Certificates of Analysis (CoA). Key parameters to verify include zinc content (typically 20–25%), heavy metals (lead <5 ppm), and microbiological limits. For large orders (100+ kg), negotiate pricing tiers and inquire about customization options like particle size or excipient blending. Auditing the manufacturer's chelation process ensures consistent quality—ask for details on raw material sourcing (e.g., pharmaceutical-grade L-histidine) and quality control steps. MOQs usually start at 25 kg, with lead times of 2–4 weeks for custom batches.
Related Manufacturers
- 主营：甘氨酸镁、微量元素、苏糖酸镁、赖氨酸锌、吡啶甲酸锌、大米螯合锌、甘氨酸螯合锌、抗坏血酸钙、抗坏血酸锰、食品添加剂、抗坏血酸锂、氨基酸螯合镁、赖氨酸甘氨酸镁
- 主营：回收钛白粉、回收硫酸铜、回收氯化亚锡、回收锌粉、回收氧化锌、回收油漆、回收石蜡、回收己内酰胺、回收水银、回收丙烯酸树脂、回收溶剂、回收硫酸亚锡、回收碳酸锂、回收碳酸钾、回收氢氧化锂、回收氢氧化钠、回收氢氧化钾、回收硼酸、回收硼砂、回收煤焦油、回收烧火油、回收环氧树脂、回收过期油漆、回收白砂糖、回收柠檬酸
- 主营：生物化工试剂、中间体、帕罗韦德中间体
- 主营：肌醇镁、植酸镁、辛酸镁、柠檬酸锌、矿物质、肌酸镁、肌酸钙、琥珀酸镁、丙酮酸钙、柠檬酸镁、苹果酸铜、粉末颗粒、乳清酸钙、苹果酸钙、植酸钙镁、柠檬酸硼、苏糖酸镁、甘氨酸钙、苹果酸镁、苏氨酸钙、赖氨酸铜、微量元素、琥珀酸钙、精氨酸镁、赖氨酸镁
- 主营：回收油漆、回收染料、回收树脂、长期收购氧化锌、回收机油、回收橡胶、回收助剂
- 主营：油漆 涂料、树脂、化工助剂、氧化锌、奶粉、石蜡、日化原料、硫酸铜、染料颜料、异氰酸酯、油墨、钛白粉、环氧树脂、聚乙烯醇、碳酸钾