Overview
Zedorafuranene is a bioactive sesquiterpene primarily extracted from Curcuma zedoaria (zedoary rhizome), a plant used in Ayurvedic and Chinese medicine. As a furanoid sesquiterpene, it contributes to the plant's characteristic aroma and therapeutic properties. Research indicates its potential role in anti-inflammatory and anticancer applications, though clinical evidence remains preliminary. The compound is typically isolated via steam distillation or solvent extraction, with purity grades varying between 70-98% for research and industrial use.
Physical and Chemical Properties
Zedorafuranene is characterized by its low-density, volatile nature, and distinct woody-aromatic odor. Its molecular structure includes a furan ring attached to a sesquiterpene backbone, contributing to both volatility and lipid solubility. Thermal stability is moderate, with decomposition observed above 260°C. The compound shows UV absorption maxima around 210-230 nm, useful for analytical identification. Its solubility profile makes it suitable for ethanol-based formulations but limits aqueous applications without emulsifiers.
Main Applications
In traditional medicine, zedorafuranene is valued for its purported digestive and anti-inflammatory effects, often formulated in essential oil blends. Modern pharmaceutical research investigates its cytotoxic activity against certain cancer cell lines. The fragrance industry utilizes it as a mid-note in oriental and woody perfumes due to its warm, earthy scent. Some studies explore its potential as a natural preservative, leveraging antimicrobial properties observed in vitro.
Safety and Storage
As a volatile organic compound, zedorafuranene requires storage in amber glass or aluminum containers under inert gas to prevent oxidation. Degradation products may form upon prolonged exposure to air or light. Safety data sheets recommend PPE including nitrile gloves and goggles when handling concentrated forms. No acute toxicity is reported, but sensitization potential warrants caution in industrial-scale processing. Disposal should follow local regulations for organic compounds.
B2B Procurement Guide
Bulk buyers should prioritize suppliers providing third-party Certificates of Analysis (CoA) detailing purity, residual solvents, and heavy metal content. Extraction method (CO2 vs. ethanol) affects price and applicability – CO2 extracts command premium pricing but offer higher consistency. Minimum order quantities typically range from 100g to 1kg for research-grade material. For GMP-compliant pharmaceutical use, expect lead times of 4-8 weeks for customized purification and documentation. Spot prices fluctuate with zedoary rhizome harvest yields.
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