Wogonin Extract
Overview
Wogonin Extract is a naturally occurring flavone isolated from the roots of Scutellaria baicalensis (Chinese skullcap). It has gained attention in biomedical research and commercial applications due to its multifunctional bioactive properties, including anti-inflammatory, antioxidant, and anticancer effects. The compound is typically extracted using ethanol or supercritical CO2 methods, followed by purification to achieve standardized potency. As a high-value botanical active, it is increasingly used in nutraceuticals, traditional medicine formulations, and modern drug development. Its mechanism of action involves modulation of signaling pathways like NF-κB and STAT3, making it a candidate for therapeutic applications in chronic diseases.
Physical and Chemical Properties
Wogonin is characterized by its flavonoid structure featuring a 5,7-dihydroxy-8-methoxy arrangement. The compound exhibits UV absorption maxima at 275 and 335 nm, useful for analytical quantification. It demonstrates stability under acidic conditions but may degrade under prolonged exposure to heat or alkaline environments. Its poor water solubility necessitates formulation strategies such as nanoemulsions or cyclodextrin complexes for enhanced bioavailability. The crystalline powder is hygroscopic, requiring desiccated storage. Spectroscopic methods (HPLC, NMR) are standard for purity verification, with commercial extracts typically offering 98–99% purity for research-grade material.
Main Applications
In pharmaceuticals, wogonin is studied for oncology applications due to its ability to induce apoptosis in cancer cells while sparing normal cells. Clinical trials explore its potential in leukemia, breast cancer, and glioblastoma therapies. Nutraceutical formulations incorporate it for liver protection and neurosupport, often combined with other Scutellaria flavonoids. The cosmetic industry utilizes wogonin in anti-aging products for its collagen synthesis promotion and UV-protective effects. Research-grade extracts serve as reference standards in pharmacological studies, particularly for investigating traditional Chinese medicine mechanisms. Emerging applications include functional foods targeting metabolic syndrome and neurodegenerative disorders.
Safety and Storage
Wogonin Extract is generally regarded as safe (GRAS) at typical dosages, with LD50 values exceeding 2 g/kg in rodent studies. However, concentrated forms require proper PPE during handling to prevent mucous membrane irritation. Occupational exposure limits have not been established, but dust control measures are recommended in industrial settings. Long-term storage stability requires protection from oxidation and moisture. Vacuum-sealed aluminum bags with desiccants are preferred for bulk quantities. For laboratory use, aliquoting into amber vials under inert gas can extend shelf life beyond 24 months when refrigerated. Regular purity testing is advised for critical applications.
B2B Procurement Guide
When sourcing Wogonin Extract, prioritize suppliers providing full analytical documentation including HPLC chromatograms, residual solvent reports, and heavy metal testing. The extraction method significantly impacts bioactivity—ethanol extracts generally preserve more active compounds than methanol alternatives. For large-scale purchases (1kg+), request pilot samples for bioassay validation. Pricing tiers typically decrease by 15–30% for orders exceeding 100g. Consider contract manufacturing for customized formulations (e.g., water-soluble derivatives). Key sourcing regions include China (for raw material advantage) and the US/EU for GMP-certified processing facilities. Lead times average 4–6 weeks for customized purity specifications.
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