Overview
The murine cannabinoid system shares significant homology with humans, making mice essential models for studying endocannabinoids (e.g., anandamide, 2-AG) and exogenous cannabinoids. These lipid-based neurotransmitters modulate pain perception, appetite, and memory through CB1/CB2 receptor interactions. Research-grade cannabinoids for murine studies include receptor agonists (WIN55,212-2), antagonists (SR141716A), and fluorescent tracers. Strict ethical guidelines govern their use in animal research, requiring Institutional Animal Care and Use Committee (IACUC) approval in most jurisdictions.
Physical and Chemical Properties
Endocannabinoids are fatty acid derivatives with low water solubility but high membrane permeability. Synthetic research cannabinoids often incorporate aromatic rings and alkyl chains to enhance receptor binding affinity or metabolic stability. Notable compounds like CP55,940 demonstrate picomolar binding affinity to CB1 receptors. Radiolabeled versions (e.g., [³H]CP55,940) enable autoradiography studies. Stability varies significantly - anandamide degrades within minutes via fatty acid amide hydrolase (FAAH), while JWH-018 derivatives persist for hours.
Main Applications
Murine models are indispensable for investigating cannabinoid effects on neurological disorders (epilepsy, Parkinson's), psychiatric conditions (anxiety, schizophrenia), and metabolic syndromes. The 1999 CB1 knockout mouse study revolutionized understanding of endocannabinoid functions. Pharmaceutical companies utilize cannabinoid-challenged mice for pharmacokinetic studies of novel analgesics. Recent breakthroughs include allosteric modulator development and biased agonism research using transgenic mouse lines expressing humanized CB receptors.
Safety and Storage
Schedule I controlled substances like Δ9-THC require DEA licensing for research use in the U.S. Non-psychoactive analogs (e.g., CBD) have fewer restrictions but still require proper documentation. Lab storage demands chemical stability considerations: Anandamide solutions require argon-blanketed vials at -80°C, while crystalline CB1 antagonists remain stable at -20°C. Material Safety Data Sheets (MSDS) must address solvent carriers (often DMSO or ethanol) alongside the active compounds.
B2B Procurement Guide
Reputable suppliers include Tocris Bioscience (research compounds), Cayman Chemical (analytical standards), and RTI International (DEA-licensed materials). Prices range from $200/mg for high-purity reference standards to $50/mg for screening compounds. Procurement requires documentation of research purpose, institutional certifications, and often import/export permits. Lead times average 4-6 weeks for controlled substances. Alternatives include using legally exempt analogs (e.g., HU-210 vs. HU-211) where scientifically appropriate.
Related Manufacturers
- 主营：ELISA试剂盒、生化检测试剂盒、PCR试剂盒、小鼠ELISA试剂盒、大鼠ELISA试剂盒、兔ELISA试剂盒、鸡ELISA试剂盒
- 主营：Elisa试剂盒、生化试剂盒、蛋白试剂盒、鼠大麻素I型受体Elisa、细胞试剂盒
- 主营：大鼠白介素、表皮生长因子、ELISA试剂盒、小鼠脂联素、细胞因子、重组蛋白
- 主营：Elisa试剂盒
- 主营：人端粒酶、试剂盒、结合蛋白、小鼠信号素3E、大鼠睾酮、抗胰蛋白酶、过氧化物酶、大鼠铁蛋白、乳酸脱氢酶、表皮调节素、丙酮酸激酶、大鼠脂多糖、糖化血清蛋白、大鼠前白蛋白、大鼠补体蛋白、大鼠纤维蛋白、神经营养因子、促卵泡生成素、肿瘤坏死因子、大鼠肌酸激酶、糖化载脂蛋白、大鼠环氧合酶、半乳糖核酸酶、大鼠糜蛋白酶、大鼠补体片段、促黄体生成素
- 主营：脂蛋白、瘤细胞、细胞株、蛋白酶、肉毒碱、信号素、测试盒、切蛋白、样蛋白、癌细胞、羧化酶、子宫肌、质激素、羧肽酶、坏血酸、合成酶、视网膜、同源物、骨钙素、羧激酶、白介素、加压素、纤溶酶、骨桥素、干扰素
- 主营：内源性大麻素、elisa试剂盒
- 主营：试剂盒、辅激活因子、elisa试剂盒、小鼠内源性大麻素、蛋白、多肽、金标试剂盒、PCR试剂盒、抗生素、氨基酸、血清、抗体
- 主营：小鼠内源性大麻素、Elisa试剂盒、检测试剂盒
- 主营：小鼠内源性大麻素、检测试剂盒、elisa试剂盒
- 主营：内源性大麻素、elisa试剂盒
- 主营：ELISA试剂盒、检测试剂盒、酶联免疫试剂盒、生物检测试剂盒、PCR试剂盒、细胞、试剂
- 主营：Elisa试剂盒、生化试剂盒、Pcr试剂盒、内源性大麻素、细胞、抗体
- 主营：gal7elisa、bmp7elisa、ctsbelisa、内源性大麻素、bmp2elisa、ang2elisa、fgf7elisa、prb4elisa、cd80elisa、bmp4elisa、bmp5elisa、gal2elisa、试剂盒、ccl7elisa、ctsdelisa、dkk3elisa、heat检测、bssp检测、fstl1elisa、edm1检测、ccn1检测、cd54检测、mic1检测、cd30lelisa、ccl16elisa、il10检测
- 主营：内源性大麻素、elisa试剂盒、pcr检测试剂盒