Overview
Wedelolactone is a bioactive coumestan derivative primarily extracted from plants like Eclipta prostrata and Wedelia calendulacea. It has garnered attention for its diverse pharmacological properties, including anti-inflammatory, hepatoprotective, and anti-cancer effects. Its molecular structure enables it to interact with various biological pathways, making it a subject of extensive research in modern medicine and traditional herbal applications. In traditional medicine, wedelolactone has been used to treat liver disorders and inflammatory conditions. Its potential in inhibiting 5-lipoxygenase and other enzymes involved in inflammation has spurred interest in developing it as a therapeutic agent. The compound is also studied for its role in protecting liver cells from damage caused by toxins and oxidative stress.
Physical and Chemical Properties
Wedelolactone is characterized by its pale yellow to brown powdery appearance and a molecular weight of 314.25 g/mol. It has a melting point around 250-252°C, indicating moderate thermal stability. The compound is soluble in organic solvents like DMSO and methanol but has limited solubility in water, which influences its formulation in pharmaceutical applications. Its chemical structure includes a coumestan core, which contributes to its biological activity. The presence of hydroxyl and ketone groups allows it to participate in hydrogen bonding and other molecular interactions, enhancing its ability to modulate enzyme activity. These properties are critical for its effectiveness in research and therapeutic contexts.
Main Applications
Wedelolactone is primarily utilized in pharmaceutical research for its anti-inflammatory and hepatoprotective effects. It is being investigated as a potential treatment for conditions like hepatitis, liver fibrosis, and certain cancers. Its ability to inhibit key enzymes involved in inflammation makes it a promising candidate for drug development. In addition to its medicinal uses, wedelolactone is incorporated into dietary supplements aimed at supporting liver health. Traditional medicine systems, particularly in Asia, have long used plants containing this compound for liver detoxification and anti-inflammatory purposes. Its dual role in modern and traditional medicine underscores its versatility and therapeutic potential.
Safety and Storage
Wedelolactone should be handled with care to avoid exposure. Proper personal protective equipment, such as gloves and eye protection, is recommended when working with the compound. Inhalation or ingestion should be avoided, as its biological activity may pose risks if improperly managed. For storage, wedelolactone should be kept in a cool, dry place, protected from light to maintain its stability. Containers should be tightly sealed to prevent moisture absorption or contamination. These precautions ensure the compound remains effective for research or commercial use over time.
B2B Procurement Guide
When procuring wedelolactone, B2B buyers should prioritize verifying the compound's purity and sourcing. Reputable suppliers should provide certificates of analysis detailing purity levels, which typically range from 95% to 98% for research-grade material. Bulk orders may require coordination with manufacturers for custom synthesis, which can affect lead times and pricing. Price ranges vary based on purity and quantity, with reference prices commonly between $50 and $200 per gram. Buyers should also consider logistical factors, such as shipping conditions and storage requirements, to ensure the compound's integrity upon delivery. Establishing long-term relationships with reliable suppliers can streamline procurement and ensure consistent quality.
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