Overview
Oleanolic acid is a naturally occurring triterpenoid compound found in various plants, including olive leaves, cloves, and some fruits. It has gained attention for its broad pharmacological effects, including anti-inflammatory, hepatoprotective, and antioxidant properties. Its water-soluble derivatives, such as sodium oleanolic acid, enhance bioavailability and expand its applications in pharmaceuticals and nutraceuticals. In traditional medicine, oleanolic acid has been used to treat liver disorders and inflammation. Modern research continues to explore its potential in combating metabolic diseases, cancer, and microbial infections. Its versatility and safety profile make it a valuable ingredient in both therapeutic and cosmetic formulations.
Physical and Chemical Properties
Oleanolic acid is a white to off-white crystalline powder with a molecular weight of 456.70 g/mol. It has a melting point around 300-310°C and is soluble in organic solvents like ethanol and DMSO but only slightly soluble in water. Water-soluble derivatives, such as sodium oleanolic acid, are developed to overcome this limitation. The compound exhibits stability under normal storage conditions but should be protected from light and moisture to prevent degradation. Its triterpenoid structure contributes to its bioactive properties, including its ability to modulate inflammatory pathways and protect cells from oxidative stress.
Main Applications
Oleanolic acid is widely used in the pharmaceutical industry for its therapeutic benefits. It is incorporated into drugs for liver protection, anti-inflammatory treatments, and diabetes management. Its antioxidant properties also make it a candidate for anti-aging and skincare products in the cosmetics industry. In the nutraceutical sector, oleanolic acid is added to dietary supplements for its potential to support cardiovascular health and immune function. Its water-soluble forms are particularly useful in liquid formulations, enhancing absorption and efficacy. Research continues to explore its applications in cancer therapy and antimicrobial treatments.
Safety and Storage
Oleanolic acid is generally regarded as safe, with low toxicity reported in clinical studies. However, standard laboratory precautions should be followed, including the use of gloves and eye protection to avoid irritation. Proper ventilation is recommended when handling the powder to prevent inhalation. Storage conditions are critical to maintaining the compound's stability. It should be kept in a cool, dry place, away from direct sunlight and moisture. Sealed containers are ideal to prevent contamination and degradation. For long-term storage, refrigeration may be considered, though it is not strictly necessary for short-term use.
B2B Procurement Guide
When procuring oleanolic acid, businesses should prioritize suppliers with verified certifications, such as GMP or ISO, to ensure product quality. Key specifications to check include purity (typically 95-98%), solubility (especially for water-soluble derivatives), and absence of heavy metals or residual solvents. Price varies based on purity, quantity, and supplier reputation. Bulk purchases often attract discounts, but it's advisable to request samples for testing before large-scale orders. Reliable suppliers provide detailed COA (Certificate of Analysis) and MSDS (Material Safety Data Sheet) documentation. Consider logistics and storage requirements, especially for temperature-sensitive shipments.
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