Overview
Vitexin Standard is a certified reference material (CRM) of the bioactive flavonoid vitexin, primarily sourced from plants like Vitex agnus-castus or Passiflora incarnata. It serves as a critical benchmark in HPLC, LC-MS, and UV-Vis analyses for quantifying vitexin content in herbal extracts, pharmaceuticals, and dietary supplements. The standard is manufactured under strict GMP/ISO guidelines to ensure traceability and reproducibility. As a C-glycosylated flavonoid, vitexin exhibits antioxidant and anti-inflammatory properties, driving its use in pharmacological studies. The standard is typically supplied with a Certificate of Analysis (COA) detailing purity (≥95-98%), chromatographic data, and stability information.
Physical and Chemical Properties
Vitexin Standard appears as a fine, white to pale-yellow crystalline powder with a molecular weight of 432.38 g/mol. Its chemical structure consists of an apigenin backbone linked to a glucose moiety at the 8-position, contributing to its moderate polarity. The compound decomposes around 250°C without a distinct boiling point. Solubility varies with solvent polarity: it dissolves readily in dimethyl sulfoxide (DMSO) and methanol but shows limited solubility in water (~1 mg/mL). Spectroscopic properties include UV-Vis absorption maxima at 270 nm and 335 nm, useful for analytical method validation. The standard is stable under inert conditions but may degrade upon prolonged exposure to light or humidity.
Main Applications
In pharmaceutical quality control, Vitexin Standard is indispensable for assay validation and impurity profiling in herbal medicines containing vitexin, such as hawthorn or chasteberry extracts. Regulatory bodies like USP and EP require CRMs for compliance testing of raw materials and finished products. Research laboratories employ the standard to investigate vitexin’s bioactivities, including its potential neuroprotective, cardioprotective, and antidiabetic effects. Nutraceutical manufacturers use it to standardize flavonoid content in supplements. Additionally, it aids in method development for food analysis, ensuring accurate quantification in plant-based beverages and functional foods.
Safety and Storage
Vitexin Standard is classified as non-hazardous under GHS criteria. However, standard laboratory precautions apply: use personal protective equipment (PPE) like gloves and goggles to minimize skin/eye contact. Inhalation risks are low due to its low volatility. For long-term stability, store unopened vials at 2-8°C in original packaging to prevent moisture absorption and photodegradation. Working solutions in organic solvents should be prepared fresh or stored at -20°C for ≤1 week. Discard discolored or precipitated samples. Suppliers typically provide stability data for specific batches upon request.
B2B Procurement Guide
When sourcing Vitexin Standard, prioritize suppliers with ISO 17034 accreditation for reference materials. Key procurement criteria include: 1) Purity level (HPLC-grade ≥98% preferred), 2) Batch-specific COA with NMR/HRMS validation, 3) Residual solvent and heavy metal testing, and 4) Minimum order quantities (MOs) for bulk purchases. Leading manufacturers include Sigma-Aldrich, ChromaDex, and Extrasynthese. Prices vary by purity (analytical grade: ~$200/g; USP-grade: up to $500/g). For research-scale trials, consider purchasing smaller quantities (e.g., 10-100 mg) to validate performance before committing to bulk orders. Request stability data and shipping conditions (cold chain recommended for international transport).
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