Overview
Vinpocetine is a semi-synthetic compound derived from vincamine, an alkaloid found in the periwinkle plant (Vinca minor). Developed in the 1970s, it is primarily used as a nootropic and vasodilator to enhance cerebral blood flow and cognitive function. Its mechanism of action includes inhibiting phosphodiesterase enzymes and modulating sodium and calcium channels, which contributes to its neuroprotective effects. In the pharmaceutical industry, vinpocetine is formulated into tablets, capsules, and injectables. It is widely prescribed in some countries for conditions like stroke recovery, dementia, and age-related cognitive decline. Despite its widespread use, regulatory status varies by region, with some countries classifying it as a prescription drug and others as a dietary supplement.
Physical and Chemical Properties
Vinpocetine is a white to off-white crystalline powder with a molecular weight of 350.46 g/mol. It has a melting point range of 147-152°C and is soluble in organic solvents like ethanol and DMSO but only slightly soluble in water. These properties make it suitable for formulation into various pharmaceutical dosage forms. The compound is stable under standard storage conditions but should be protected from light and moisture to prevent degradation. Its solubility profile dictates the need for specific solvents in laboratory and industrial applications. Analytical methods such as HPLC and UV spectroscopy are commonly used to assess its purity and stability.
Main Applications
Vinpocetine is primarily used in the treatment of cerebrovascular disorders and cognitive impairments. It is effective in improving cerebral blood flow and oxygen utilization, making it valuable for conditions like ischemic stroke, vascular dementia, and memory disorders. Clinical studies suggest it may also have antioxidant and anti-inflammatory properties. Beyond pharmaceuticals, vinpocetine is included in some dietary supplements aimed at enhancing mental performance. However, its efficacy in healthy individuals remains debated. In research, it serves as a tool compound for studying neuroprotection and cerebral metabolism. Regulatory approvals vary, with some countries restricting its use to prescription-only status.
Safety and Storage
Vinpocetine is generally well-tolerated, with mild side effects such as gastrointestinal discomfort, dizziness, or flushing reported in some cases. It is contraindicated in pregnant women due to insufficient safety data. Proper storage involves keeping the compound in a cool, dry place, sealed tightly to avoid exposure to moisture and light. Industrial handling requires standard laboratory precautions, including the use of gloves and eye protection. Bulk storage should comply with pharmaceutical-grade standards to ensure stability. Disposal should follow local regulations for chemical waste, avoiding environmental contamination.
B2B Procurement Guide
When procuring vinpocetine, B2B buyers should prioritize suppliers with certified Good Manufacturing Practice (GMP) compliance. Key specifications include purity (≥98%), confirmed by third-party testing, and the absence of heavy metals or residual solvents. Packaging options range from small quantities for research to bulk kilograms for pharmaceutical production. Price negotiations should consider factors like order volume, purity grade, and supplier reputation. Long-term contracts may offer cost advantages. Buyers should also verify regulatory compliance in their target markets, as requirements vary by region. Reliable suppliers often provide technical support and documentation, including Certificates of Analysis (CoA).
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