Overview
Human Urocanase Domain-Containing Protein 1 (UROC1) is an enzyme that catalyzes the conversion of urocanate to imidazolonepropionate, a key step in histidine metabolism. This protein is encoded by the UROC1 gene and is primarily expressed in the liver and kidneys. UROC1 plays a vital role in the degradation of histidine, an essential amino acid, and its activity is crucial for maintaining metabolic balance. Research on UROC1 has expanded our understanding of histidine metabolism and its implications in various physiological and pathological conditions. The enzyme's structure and function are of particular interest to biochemists and molecular biologists, as they provide insights into metabolic disorders and potential therapeutic targets.
Physical and Chemical Properties
UROC1 is a protein with a molecular weight ranging approximately between 50-60 kDa, depending on post-translational modifications. It typically exists as a lyophilized powder or in liquid solution for laboratory use. The enzyme is soluble in aqueous buffers, making it suitable for in vitro studies. The enzymatic activity of UROC1 is highly dependent on pH and temperature, with optimal activity observed under physiological conditions. The protein's stability can be affected by factors such as storage temperature and exposure to proteolytic enzymes, necessitating careful handling and storage to preserve its functionality.
Main Applications
UROC1 is primarily used in biochemical research to study histidine metabolism and its regulatory mechanisms. Its role in converting urocanate to imidazolonepropionate makes it a valuable tool for investigating metabolic pathways and disorders related to histidine degradation. Additionally, UROC1 has potential applications in the development of diagnostic assays for metabolic diseases. Researchers are exploring its utility as a biomarker for conditions such as histidinemia, a rare genetic disorder characterized by impaired histidine metabolism. The enzyme's specificity and activity also make it a candidate for use in enzymatic assays and biotechnological applications.
Safety and Storage
When handling UROC1, standard laboratory safety precautions should be followed, including the use of personal protective equipment such as gloves and lab coats. The enzyme should be stored at -20°C to maintain its stability and prevent degradation. Repeated freeze-thaw cycles should be avoided, as they can reduce enzymatic activity. In case of exposure, rinse affected areas with water and seek medical advice if necessary. Proper disposal methods should be followed in accordance with local regulations for biochemical reagents. Always refer to the material safety data sheet (MSDS) provided by the supplier for specific safety information.
B2B Procurement Guide
When procuring UROC1 for research or industrial purposes, it is essential to verify the purity and enzymatic activity specifications provided by the supplier. Reputable suppliers often provide certificates of analysis (CoA) detailing these parameters. Purity levels of 90% or higher are commonly required for research applications. Price ranges for UROC1 can vary significantly depending on the supplier, quantity, and purity. For reference, research-grade UROC1 may cost approximately $200-$500 per milligram. Bulk purchases may offer cost savings, but it is advisable to confirm stability and storage requirements for larger quantities. Ensure that the supplier complies with relevant quality standards and provides adequate technical support.
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