Overview
Uridine is a naturally occurring nucleoside composed of uracil attached to a ribose sugar via a β-N1-glycosidic bond. It is a fundamental component of RNA and participates in various biochemical pathways, including glycogen synthesis and phospholipid metabolism. Industrially, uridine is produced via fermentation or chemical synthesis for applications in pharmaceuticals and biotechnology. As a pyrimidine nucleoside, uridine serves as a precursor for nucleotides like UTP (uridine triphosphate) and is involved in cell signaling. Its derivatives, such as uridine-5'-monophosphate (UMP), are critical in research and therapeutic development.
Physical and Chemical Properties
Uridine appears as a white, odorless crystalline powder with moderate solubility in water (approximately 50 mg/mL at 25°C) and limited solubility in organic solvents. It exhibits UV absorption maxima at 262 nm (pH 7), a characteristic feature for quantification via spectrophotometry. The compound is stable under dry, cool conditions but may degrade upon prolonged exposure to moisture or heat. Its melting point with decomposition (165-168°C) distinguishes it from related nucleosides. Chemical modifications, such as phosphorylation or acetylation, alter its properties for specialized applications.
Main Applications
In pharmaceuticals, uridine is used to synthesize antiviral drugs (e.g., idoxuridine) and chemotherapy adjuvants to mitigate toxicity. It also serves as a raw material for mRNA vaccine production due to its role in RNA synthesis. Research laboratories utilize uridine to study nucleic acid metabolism, neuronal function, and mitochondrial disorders. In nutraceuticals, it is marketed as a cognitive enhancement supplement, though clinical evidence remains limited. Industrial-scale applications include microbial fermentation processes to produce nucleotide-derived flavor enhancers.
Safety and Storage
Uridine is classified as low-risk under standard laboratory handling. No significant acute toxicity is reported, but dust inhalation or eye contact should be avoided. Use personal protective equipment (PPE) including gloves and safety goggles during bulk handling. Store in tightly sealed containers under refrigeration (2-8°C) to prevent hygroscopic degradation. Shelf life typically exceeds two years when stored properly. Dispose of waste according to local regulations for organic compounds.
B2B Procurement Guide
For bulk procurement, prioritize suppliers with ISO 9001 or cGMP certification to ensure consistency. Key specifications include HPLC purity (≥98%), residual solvent levels (e.g., <0.1% ethanol), and endotoxin testing for biomedical applications. Request certificates of analysis (CoA) and stability data. Packaging options range from 1 kg aluminum foil bags to 25 kg fiber drums with desiccants. Lead times vary by quantity; spot purchases of research-grade uridine (5-100g) are typically available, while metric-ton orders may require 4-8 weeks for production.
Related Manufacturers
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、蛋白、抗体、细胞、检测试剂盒
- 主营：ELISA试剂盒、PCR试剂盒、科研试剂
- 主营：甜菊糖、氯乙酰、二乙苯、脱水尿苷、酞菁绿、阻燃剂、4316-73-8、二戊烯、单甲醚、硫酸锂、4861-19-2、大理石、1192-62-7、羊脂酸、7783-40-6、磷酸氢、8002-74-2、7782-61-8、龙脑油、2842-44-6、聚甘油、二聚酸、戊二醇、聚醚f68、磺化油、1310-58-3
- 主营：ELISA试剂盒、抗体
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、脂蛋白、关基因、亲环素、钾通道、列抗体、ntp溶液、蛋白酶、脑蛋白、病毒抗、蛋白质、239抗体、dtt溶液、科研试剂
- 主营：检测方、试剂盒、同源物、钠尿肽、ep300检测、结合蛋白、大鼠c-肽(、微球蛋白、抗胰蛋白酶、淋巴瘤因子、蛋白磷酸酶、死亡激动剂、核心域蛋白1、大鼠e选择素、大鼠janus激酶、激活蛋白激酶、大鼠ⅱ型胶原、大鼠ⅳ型胶原、大鼠klotho蛋白、细胞激活因子、大鼠ⅲ型胶原、大鼠nadh脱氢酶1、大鼠ⅵ型胶原α1、elisa 检测试剂盒
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、蛋白、抗体、细胞
- 主营：尿苷、高铁酸钾
- 主营：10ul吸头、巴氏吸管、离心管、透析袋、琼脂糖、国产试剂
- 主营：有机原料、中间体、香精香料、催化剂、有机硅、表面活性剂
- 主营：尿苷、麦芽糖酸、苯氧基环磷腈、甲巯基四氮唑
- 主营：Elisa试剂盒、检测试剂盒、人elisa试剂盒、尿嘧啶核苷磷酸化酶1、鼠elisa试剂盒、PCR检测试剂盒、生物试剂盒
- 主营：检测试剂盒
- 主营：试剂盒、信号调节激酶、人转谷氨酰胺酶