Tulathromycin
Overview
Tulathromycin is a semi-synthetic macrolide antibiotic derived from erythromycin. It is specifically formulated for veterinary use, particularly in treating respiratory infections in livestock. Developed by Pfizer Animal Health, it is marketed under the brand name Draxxin. Its mechanism of action involves binding to the 50S ribosomal subunit of bacteria, inhibiting protein synthesis. This makes it effective against pathogens like Mannheimia haemolytica, Pasteurella multocida, and Mycoplasma bovis.
Physical and Chemical Properties
Tulathromycin is a white to off-white crystalline powder with a molecular weight of 806.08 g/mol. It is soluble in water and organic solvents like methanol and ethanol. The compound is stable under recommended storage conditions but degrades at high temperatures or in acidic environments. Its melting point ranges between 140-145°C, and it exhibits broad-spectrum antibacterial activity. The solubility and stability profiles make it suitable for injectable and oral formulations in veterinary applications.
Main Applications
Tulathromycin is primarily used in veterinary medicine to treat bovine respiratory disease (BRD) and swine respiratory disease (SRD). Its long-acting formulation ensures sustained therapeutic levels, reducing the need for frequent dosing. It is also effective against secondary infections caused by Mycoplasma species. The antibiotic is administered via subcutaneous or intramuscular injection, with dosage tailored to animal weight and infection severity.
Safety and Storage
Tulathromycin should be stored in a cool, dry place (2-8°C) and protected from light and moisture. Prolonged exposure to high temperatures or humidity can degrade the compound. Safety precautions include wearing gloves and masks during handling to avoid skin contact or inhalation. Proper disposal methods should follow local regulations to prevent environmental contamination.
B2B Procurement Guide
When procuring Tulathromycin, verify the CAS number (217500-96-4) and ensure compliance with regional veterinary regulations. Bulk orders typically offer cost advantages, but suppliers should provide certificates of analysis (CoA) for purity verification. Prices range from approximately $100-$300 per kg, depending on purity and supplier. Establish long-term contracts with reputable manufacturers to ensure consistent quality and supply.
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