Overview
Triiodothyronine (T3) is one of two primary hormones produced by the thyroid gland, playing a pivotal role in regulating basal metabolic rate, protein synthesis, and cellular differentiation. As the more biologically active form compared to thyroxine (T4), T3 directly influences nearly every physiological process in vertebrates. Chemically classified as an iodinated tyrosine derivative, T3 is synthesized both in the thyroid gland and peripherally through enzymatic deiodination of T4. Its discovery in 1952 revolutionized endocrinology, leading to advanced treatments for thyroid disorders.
Physical and Chemical Properties
T3 crystallizes as a light-colored powder with characteristic iodine odor. The molecule contains three iodine atoms at positions 3, 5, and 3' on the tyrosine rings, contributing to its hormonal activity and stability. The phenolic hydroxyl group at position 4' is essential for receptor binding. Its poor water solubility necessitates alkaline solutions (e.g., NaOH) for laboratory preparations. The compound shows UV absorption maxima at 225 nm and 318 nm, useful for analytical quantification. Thermal decomposition occurs before boiling, requiring careful handling during formulation processes.
Main Applications
In medicine, T3 is formulated as liothyronine sodium for treating hypothyroidism and myxedema coma, offering faster action than levothyroxine. It's particularly valuable when rapid thyroid hormone replacement is critical. Research applications include metabolic studies, where T3 serves as a key reagent for investigating thermogenesis, cardiac function, and brain development. Biotechnology companies utilize T3 in cell culture media for stem cell differentiation protocols and metabolic assays.
Safety and Storage
As a potent endocrine disruptor, T3 requires strict handling protocols. Laboratory personnel must use PPE including nitrile gloves and protective eyewear when handling powdered forms. Spills should be contained with absorbent materials and disposed as biohazard waste. Long-term storage demands amber glass vials with desiccants at refrigerated temperatures (2-8°C). Solutions should be prepared fresh and used within 24 hours due to oxidation risks. Inventory management systems should track expiration dates, as degraded T3 may form potentially toxic iodinated byproducts.
B2B Procurement Guide
Pharmaceutical buyers should prioritize suppliers with GMP certification and batch-specific CoA documentation, verifying identity (HPLC retention time), purity (≥98%), and residual solvent levels. Research-grade purchases require additional endotoxin testing for cell culture applications. Bulk procurement (100g+) typically offers 15-30% cost reductions, but necessitates stability testing for extended storage. Emerging markets in Asia now provide competitive alternatives, though importers must ensure compliance with destination-country pharmacopeia standards (USP/EP/JP).
Related Manufacturers
- 主营：ELISA试剂盒、PCR试剂盒、科研试剂
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、蛋白、抗体、细胞、检测试剂盒
- 主营：ELISA、分光光度法、微量法、植物ELISA 试剂盒、ELISA试剂盒、大鼠试剂盒、小鼠试剂盒、人试剂盒、植物试剂盒、酶联免疫法、MEGAZYME、大鼠ELISA试剂盒、小鼠ELISA试剂盒、人ELISA试剂盒、白介素试剂盒、细胞因子试剂盒、激素试剂盒、科研试剂盒、化学试剂、检测试剂盒、土壤试剂盒、土壤酶活性检测
- 主营：氯霉素、糖蛋白、试剂盒、小鼠三碘甲状腺原氨酸、脂蛋白、胆固醇、钙蛋白、粘液素、调蛋白、磷酸酶、人嗅素、饥饿素、磷脂酶、抑制因、凝血酶、连接酶、凝集素、分泌酶、白介素、胰岛素、阻滞剂、结合盒、防御素、纤溶酶、干扰素、板层素
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、脂蛋白、关基因、亲环素、钾通道、列抗体、ntp溶液、蛋白酶、脑蛋白、病毒抗、蛋白质、239抗体、dtt溶液、科研试剂
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、生化试剂盒、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、科研试剂
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒
- 主营：ELISA试剂盒、抗体
- 主营：抑制物、糖蛋白、试剂盒、人精氨酸酶、释放因子、人色氨酰、炎性蛋白、刺激因子、生长因子、武装因子、钙黏蛋白、淋巴细胞、成孔蛋白、趋化因子、人促睡眠肽、免疫球蛋白、节苷脂抗体、二聚化蛋白、人β葡糖苷酶、人β内酰胺酶、肝炎病毒抗体、活化黏附因子、凋亡抑制因子、人潜伏膜蛋白、人二氢嘧啶酶
- 主营：生物素修饰蛋白、fitc标记蛋白、聚苯乙烯微球、三碘甲状腺原氨酸、pvc微球、嵌段共聚物、生物素标记、荧光标记、纳米颗粒、核苷糖、aie、复合微球、功能化载玻片、荧光染料、金属配合物、Mxene、介孔二氧化硅微球、磁性纳米颗粒、小分子PEG、聚合物、纳米金、聚合物微球、荧光微球、荧光探针、点击化学、小分子
- 主营：试剂盒、ELISA试剂盒、PCR试剂盒、科研细胞系
- 主营：试剂盒、ELISA试剂盒、科研ELISA试剂盒、高敏三碘甲状腺原氨酸、PCR试剂盒、生化试剂盒
- 主营：ELISA试剂盒、PCR试剂盒、科研试剂
- 主营：检测试剂盒