Overview
Gallamine Triethiodide is a synthetic neuromuscular blocking agent belonging to the class of non-depolarizing muscle relaxants. It was historically used in human and veterinary anesthesia to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgical procedures. The compound acts by competitively antagonizing acetylcholine at nicotinic receptors in the neuromuscular junction. While its use in human medicine has declined due to the development of newer agents, it remains a compound of interest in pharmacological research and some veterinary applications.
Physical and Chemical Properties
Gallamine Triethiodide presents as a white to off-white crystalline powder with good solubility in water. The compound is hygroscopic and requires careful storage to maintain stability. Its molecular structure features three quaternary ammonium groups, contributing to its pharmacological activity. The substance decomposes upon melting rather than showing a clear melting point, which is characteristic of many quaternary ammonium compounds. Its stability in solution is pH-dependent, with optimal stability observed in slightly acidic to neutral conditions.
Main Applications
The primary application of Gallamine Triethiodide has been in clinical anesthesia to produce muscle relaxation during surgical procedures. It was particularly useful for abdominal surgeries and orthopedic procedures requiring complete muscle paralysis. In veterinary medicine, it finds occasional use in large animal anesthesia. The compound also serves as a reference standard in pharmacological studies investigating neuromuscular blocking agents and their mechanisms of action.
Safety and Storage
Gallamine Triethiodide requires careful handling due to its potent pharmacological effects. Proper personal protective equipment including gloves and masks should be worn when handling the powder form to prevent accidental inhalation or skin contact. For storage, the compound should be kept in tightly sealed containers protected from light and moisture. Desiccants may be used in the storage environment to maintain stability. The material has a shelf life of approximately 2-3 years when stored under optimal conditions.
B2B Procurement Guide
When procuring Gallamine Triethiodide for pharmaceutical or research purposes, buyers should verify the supplier's certification and compliance with relevant pharmacopoeia standards (USP, EP, or BP). The certificate of analysis should confirm purity (typically ≥98%) and include results of identity tests. Bulk purchases may require special import/export permits due to the compound's pharmacological classification. Lead times for specialty orders can range from 2-6 weeks depending on supplier inventory and regulatory requirements.
Related Manufacturers
- 主营：木质醛、酮锌吡、褪黑素、三羟基、磷酸三、甘油酯、粘蛋白、薄荷脑、苯氨基、苹果酸、皮粉五、甲基蓝、生根粉、动力精、薄荷酮、二羟基、3α羟基、萘酰胺、胶粘剂、嗪二酮、氨酸钾、嘧啶酮、氨酸镁、407环氧、酸cas号
- 主营：三碘季铵酚、白蜡树素、百两金素、半齿泽兰素
- 主营：荧光素酶、血管紧张素转化酶、乳酸氧化酶、脱氧核糖核酸酶1型、乙酰胆碱酯酶、硫酸软骨素ABC酶、肝素酶
- 主营：恶霜灵、溴虫腈、标准品、草铵膦、雌酚酮、氟环唑、苯甲酸、大观霉素、恶唑菌酮、异丙氧磷、多拉菌素、氘代甲苯、呋喃西林、氟罗沙星、3-二氯丙烯、吡氟氯禾灵、二氯吡啶酸、二甲基吗啉、一氯二溴甲烷、硝基呋喃妥因
- 主营：萘苯胺、甘氨酸、甘氨酰、萘酚绿、磷酸铵、辛基酚、碘乙烷、硫酸锌、二苯胍、羟钴胺、牛磺酸、褪黑素、肉桂醇、中性红、碳酸镁、肉桂醛、视黄醛、丙炔酸、alliinase、茜素红、肠激酶、达比加、脯氨酸、异丁苯、叶绿素