Trans-Hydroxycitric Acid

Updated: 2026-09-16

Overview

Trans-Hydroxycitric Acid (HCA) is a naturally occurring derivative of citric acid, primarily extracted from the rind of the Garcinia cambogia fruit. It is widely studied for its potential metabolic benefits, particularly in weight management and lipid metabolism regulation. The compound is known for its ability to inhibit ATP-citrate lyase, an enzyme involved in fatty acid synthesis. In industrial and pharmaceutical contexts, HCA is valued for its chelating properties and role as a biochemical intermediate. Its applications span dietary supplements, functional foods, and research chemicals, making it a versatile compound in B2B markets.

Physical and Chemical Properties

Trans-Hydroxycitric Acid appears as a white to off-white crystalline powder with a molecular weight of 208.12 g/mol. It is soluble in water and slightly soluble in ethanol, with a melting point around 180-185°C, where it begins to decompose. The compound exhibits stability under standard storage conditions but may degrade when exposed to excessive heat or moisture. Chemically, HCA is noted for its ability to chelate divalent metal ions, a property leveraged in both industrial and biological applications. Its structural similarity to citric acid allows it to competitively inhibit key metabolic enzymes, contributing to its physiological effects.

Main Applications

The primary use of Trans-Hydroxycitric Acid is in the dietary supplement industry, where it is marketed for its purported weight management benefits. It is often formulated into capsules, tablets, or powdered blends targeting fat metabolism. Clinical studies have explored its role in reducing appetite and inhibiting lipogenesis, though results vary. Beyond supplements, HCA is utilized in pharmaceuticals as a chiral building block and in research settings to study metabolic pathways. Its chelating properties also make it useful in niche industrial applications, such as metal ion sequestration in water treatment or catalysis.

Safety and Storage

Trans-Hydroxycitric Acid is generally considered safe for consumption at recommended doses, though excessive intake may cause gastrointestinal discomfort. Regulatory bodies like the FDA classify it as GRAS (Generally Recognized as Safe) for specific uses. Proper handling includes wearing gloves and eye protection to avoid irritation. Storage requires a cool, dry environment (below 25°C) in tightly sealed containers to prevent moisture absorption and degradation. Bulk quantities should be stored in inert atmospheres or desiccated conditions to maintain purity. Always refer to the Material Safety Data Sheet (MSDS) for detailed hazard and first-aid information.

B2B Procurement Guide

When sourcing Trans-Hydroxycitric Acid, prioritize suppliers with certifications like ISO, GMP, or USP to ensure quality. Key specifications to verify include purity (≥98% by HPLC), heavy metal content (<10 ppm), and microbial limits. Request batch-specific Certificates of Analysis (CoA) and third-party testing reports. Pricing varies based on purity (pharmaceutical vs. industrial grade) and order volume, with bulk purchases typically discounted. Consider logistics such as shelf life (2-3 years) and shipping conditions (ambient vs. refrigerated) to avoid product degradation. Establish long-term contracts with reliable suppliers to mitigate price volatility.