Overview
Tizoxanide is a thiazolide compound and the active metabolite of nitazoxanide, a widely used antiparasitic drug. It was developed to treat infections caused by protozoa and helminths, particularly in the gastrointestinal tract. Its mechanism involves interfering with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme, essential for anaerobic energy metabolism in parasites. Due to its broad-spectrum efficacy, tizoxanide is utilized in both human and veterinary medicine. It is effective against Cryptosporidium parvum, Giardia lamblia, and other pathogens. The compound's low toxicity profile makes it suitable for pediatric and immunocompromised patients.
Physical and Chemical Properties
Tizoxanide appears as a pale yellow crystalline powder with a molecular weight of 265.25 g/mol. It has a melting point range of 198-202°C and is slightly soluble in water but dissolves well in organic solvents like DMSO. The compound is stable under standard storage conditions but degrades upon prolonged exposure to light or moisture. Its chemical structure includes a nitro-thiazole ring and a benzamide group, contributing to its antiparasitic activity. The nitro group is critical for its redox properties, enabling interference with parasitic energy pathways. Analytical methods like HPLC and mass spectrometry are commonly employed for purity assessment.
Main Applications
Tizoxanide is primarily used to treat protozoal infections such as cryptosporidiosis and giardiasis, especially in immunocompromised individuals. It is also effective against helminthic infections like fascioliasis. In veterinary medicine, it is administered to livestock to control parasitic outbreaks. The compound is often formulated as oral suspensions or tablets for human use. Combination therapies with other antiparasitics are under research to enhance efficacy. Off-label uses include experimental treatments for viral infections, though clinical evidence is limited.
Safety and Storage
Tizoxanide is generally well-tolerated, with mild side effects like nausea or abdominal pain reported in rare cases. Proper handling requires gloves and masks to avoid inhalation or skin contact. Storage should be in airtight containers at room temperature, protected from light and humidity. Disposal must comply with local hazardous waste regulations due to its bioactive nature. Spills should be contained using absorbent materials and cleaned with appropriate solvents. Always refer to the Material Safety Data Sheet (MSDS) for detailed guidelines.
B2B Procurement Guide
When procuring tizoxanide, prioritize suppliers with Good Manufacturing Practice (GMP) certification. Request a Certificate of Analysis (COA) to verify purity, typically ≥98%. Bulk purchases may qualify for discounts, but ensure proper storage during transit to prevent degradation. Pricing varies based on quantity and supplier location, with reference ranges of $50-$100 per gram. Consider long-term contracts for stable supply chains. Regulatory compliance, including FDA or EMA approvals, is critical for pharmaceutical-grade material.
Related Manufacturers
- 主营：莪术二酮、人参皂苷rc、自制对照品、替唑尼特、淫羊藿次苷
- 主营：砷酸锂、白云石、水合物、氮化锌、144205-68-5、二叔丁基、利多卡因、碳化钨钴、泛影葡胺、化合物库、1093222-27-5、羟基苯基、八钼酸铵、生化试剂、苯甲酸乙酯、熊去氧胆酸、胆酸二水合、乙酰丙酮锌、湿法云母粉、六氟磷酸盐、干法云母粉、苯碳酸甲酯、脱氧胆酸二水、氨基二琥珀酸、对乙酰氨基苯酚