Three-arm Polyethylene Glycol
Overview
Tri-arm PEG is a branched derivative of polyethylene glycol (PEG) featuring three reactive hydroxyl terminals. Its star-shaped structure enhances functionality in cross-linking and conjugation, distinguishing it from linear PEG. The compound is synthesized through controlled polymerization, with molecular weights tailored for specific applications. Widely adopted in biomedical and material sciences, tri-arm PEG serves as a versatile scaffold for drug carriers, hydrogels, and surface coatings. Its biocompatibility and tunable properties align with FDA and EMA guidelines for pharmaceutical excipients.
Physical and Chemical Properties
Tri-arm PEG exhibits low polydispersity and high solubility in polar solvents due to its hydrophilic ethylene oxide units. The hydroxyl groups at each arm enable facile modification via esterification or etherification. Thermal stability is moderate, with decomposition occurring above 200°C. The density (~1.1 g/cm³) and melting point (55–60°C) vary slightly with molecular weight. Its non-immunogenic nature and resistance to protein adsorption make it ideal for in vivo applications.
Main Applications
In drug delivery, tri-arm PEG forms stable micelles or nanoparticles, improving drug solubility and circulation time. Its three-arm structure enhances payload capacity compared to linear PEG. For hydrogels, it acts as a cross-linker, providing mechanical strength and controlled degradation. The compound is also used in bioconjugation to attach proteins or peptides, leveraging its terminal reactivity. In material science, it modifies surfaces to reduce fouling or enable biofunctionalization.
Safety and Storage
Tri-arm PEG is generally recognized as safe (GRAS) for biomedical use but requires proper handling to avoid dust inhalation. Storage at 2–8°C in sealed containers prevents moisture absorption and degradation. Disposal should follow local regulations for non-hazardous polymers. Material Safety Data Sheets (MSDS) from suppliers provide specific hazard and first-aid measures.
B2B Procurement Guide
Buyers should prioritize suppliers with ISO 13485 or cGMP certifications for biomedical-grade tri-arm PEG. Key specifications include molecular weight (e.g., 1kDa, 5kDa), polydispersity index (<1.2), and end-group functionality. Bulk procurement (≥10kg) may reduce costs by 20–30%. Sample testing for endotoxin levels (<0.5 EU/mg) is critical for injectable applications. Lead times typically range from 2–6 weeks.
Related Manufacturers
- 主营：反应活、hydrazide、修饰剂、两臂聚乙二醇、催化剂、糖蛋白、连接子、激动剂、聚合物、活性脂、胆固醇、钆特酸、催化性、dna标记、络合剂、荧光试剂、雨蛙素、乙二胺、ped结构、衍生物、化合物、链接剂、反应物、生物素
- 主营：碳材料、c60粉体、cotg昂星、双层昂星、分析仪bet、cvd石墨烯、单层昂星、3d多层独立、电位分析仪、富勒醇昂星、双层石墨烯、石墨烯昂星、油橄榄油荷、石墨烯粉体、荧光光谱仪、工业熔喷布、氧化石墨烯、氟化石墨烯、石墨烯薄膜、石墨烯浆料、水分测定仪、单层石墨烯、辅助激光解、水凝胶原液、漫反射测试昂
- 主营：甲氧基聚乙二醇、氨基聚乙二醇、羧基聚乙二醇、巯基聚乙二醇、羟基聚乙二醇、马来酰亚胺聚乙二醇、四臂聚乙二醇、荧光素聚乙二醇、叠氮聚乙二醇、硅烷聚乙二醇、炔基聚乙二醇、生物素聚乙二醇、丙烯酸酯聚乙二醇、活性脂聚乙二醇、Boc保护基团聚乙二醇、Fmoc保护基团聚乙二醇、生物素小分子PEG衍生物、甲氧基小分子PEG衍生物
- 主营：催化剂、peg试剂、cy5四氮、聚乙二醇、活性脂、苯二胺、2406-34-0、乙氧基、试剂cas、环辛烯、生物素、cb-cyclam、实验室、dbco-acid、半乳糖、溴苯基、交联剂、环己炔、荧光素、3694-51-7、ac4galnal、2001-96-9、葡萄糖、环辛炔、直发cas、糖化学
- 主营：乙醛酸、铁甲酸、二甲基、磷酸三甲酯、羟乙基、草酰胺、3-氯丙炔、邻苯二甲、苯甲酰胺、溴氯海因、3-氯水扬酸、2-羟基喹喔啉、2-苯并唑啉酮、对羟基苯海因、3-环戊二羧酸、6-二氯异烟酸、2-氨基-5-氯苯酚
- 主营：四臂聚乙二醇、荧光染料、花青素染料
- 主营：二甲基甲酰胺DMF、乙二醇二醋酸酯EGDA、环己酮、丙二醇甲醚醋酸酯PMA、二价酸酯DBE、醋酸乙酯、EPMA、正丁醇、异丙醇、丙二醇甲醚PM、聚甲氧基二甲醚DMM、二甲苯、乙二醇、甲醇、乙二醇丁醚、二甲基二硫醚、丙二醇、乙二醇乙醚醋酸酯、二辛酯、苯酚
- 主营：增塑剂、二甲基亚砜、顺酐、环丁砜、二甲基二硫醚、赋臭剂、四氢噻吩加臭剂、环戊烷、塑化剂、二辛酯、石油醚、异丁醇、氯化苄、叔十二硫醇、硬脂酸钙、树脂涂料、四氢噻吩、化学试剂、国标染料、氯乙酸、硬脂酸锌、乙二醛、异辛烷、橡胶塑料
- 主营：硫酸铜、除磷剂、溶剂油、丙三醇、三乙胺、二甲苯、双戊烯、胶黏剂、葡萄糖、正丙醇、环己胺、暖宝宝、四甲苯、锂电池、无水糖、压敏胶、维生素、乙二胺、二甘醇、丁二醇、络合剂、去味剂、乙二醇、显示屏、纤维素
- 主营：二甘醇、四甘醇、丙二醇、三甘醇、三乙二醇丁醚、三醋酸甘油酯、三乙醇胺、1.3-丙二醇、二丙二醇、异己二醇、乙二醇丁醚、二乙二醇丁醚、丙二醇甲醚、二丙二醇甲醚、丙二醇丁醚、二丙二醇丁醚、乙二醇、甘油、正庚烷、异丙醇、异辛醇、一乙醇胺、二乙醇胺、太古油40%/60%、分散剂NNO系列
- 主营：消泡剂、润湿剂、增溶剂、聚乙二醇二缩水甘油醚、环氧树脂、防缩孔剂、水性色浆、丙二醇苯醚、防腐杀菌剂、缩水甘油醚、树脂乳化剂、橡胶热敏剂、色浆分散剂、植绒胶乳化剂
- 主营：防冻液、乙二醇、丙二醇、三乙醇胺、工业级三乙醇胺、防冻剂、水泥助磨剂、印刷油墨助剂、化妆品增稠剂、防冻液原液、工业级乙二醇、涤纶级乙二醇、乙二醇厂家、甘醇、乙二醇防冻液、空气能防冻液、冷却液、工业级甘醇、国标乙二醇、涤纶级防冻液、聚酯级乙二醇、含量99%乙二醇
- 主营：丙二醇、醋酸丁酯、二丙酮醇、三乙二醇、单乙醇胺、四氢糠醇、二价酸酯、甲基丙烯酸羟乙酯、腰果酚、异氟尔酮、丙烯酸、二乙二醇丁醚、乙醇、妥尔油、磷酸、碳酸丙烯脂、二丙二醇甲醚、二甲基亚砜、邻苯二甲酯二甲酸、轻质石油醚、溶剂油、二甲基甲酰胺、N甲基二乙醇胺
- 主营：清洗剂、阻燃剂、稀释剂、丙三醇、三乙二醇、聚乙二醇、润滑剂、丁二醇、固化剂、助焊剂、甲酸钠、纺织助剂、印染助剂、皮革助剂、溶剂涂料、橡胶涂料、涂料油墨、二乙二醇、异氰酸酯、防水乳液、碳酸丙烯酯、定制碳酸钾、碳酸二甲酯、清洗去油剂、塑料增塑剂
- 主营：丙二醇、丙烯酸、异丙醇、三乙胺、三乙醇胺、无水乙醇、棕榈油、环己烷、苯酚、甲醇、甲基丙烯酸甲酯、丙烯酸羟乙酯、二甲基亚砜、苯扎溴铵、醋酸乙烯、丙烯酸丁酯、乙腈、二甲苯、二甲基硅油、丙烯酸甲酯、丙烯酸异辛酯、丙烯酸羟丙酯、二甲基海因、二甲基甲酰胺DMF
- 主营：柠檬酸、乳化剂、苯甲醇、三甘醇、三乙二醇、三甲醇丙烷、乙二酸、丙二醇、酒石酸钾钠、无水草酸、麦芽糊精、一乙醇胺、二甘醇、植物油酸、大苏打、异辛醇、硫代硫酸钠、磷酸二氢钠、二丙二醇、一水葡萄糖、葡萄糖酸钠、椰树硬脂酸、表面活性剂、食品级甘油、二甲苯磺酸钠
- 主营：正己烷、苯乙烯、异丙醇、溶剂油、叔丁醇、正庚烷、醋酸丁酯、环氧树脂、二氯甲烷、乙酸乙酯、醋酸甲酯、n-甲基甲胺、多乙烯多胺、丙烯酸甲酯、金属清洗剂、甲基丙烯酸、二乙氨基乙醇
- 主营：干燥机、混合机、制粒机、三维运动混合机、旋转闪蒸干燥机、真空耙式干燥机、离心喷雾干燥机、振动流化床干燥机、双锥回转真空干燥机、空心桨叶干燥机、沸腾干燥机、沸腾制粒机、沸腾制粒干燥机、30B粉碎机、热风循环烘箱、闪蒸干燥机、耙式干燥机、喷雾干燥机、流化床干燥机、粉碎机、旋转闪蒸烘干机、真空耙式烘干机、离心喷雾烘干机、振动流化床烘干机、沸腾干燥制粒机
- 主营：二氧化硒、硫氰酸钠、对甲苯磺酸、三硫代碳酸钠、九水硫化钠、硫化钡、氢氧化钡、苯甲酰氯、还原铁粉、氟硅酸铵、氟化钾、黄血盐钾、氟化钠、黄血盐钠、过氧化苯甲酰、AC发泡剂、异丙醇铝、4-对二氯苄、多硫化钠、铁氰化钾、对苯二甲酸二甲酯、5-羟甲基糠醛、丙酮肟、聚六亚甲基胍盐酸盐、铁粉