Overview
Tetrandrine is a bioactive alkaloid isolated from the roots of Stephania tetrandra, a plant used in traditional Chinese medicine for centuries. It belongs to the bisbenzylisoquinoline class and is recognized for its dual role as a calcium channel blocker and anti-inflammatory agent. The compound has garnered significant interest in modern pharmacology due to its potential therapeutic applications, including cancer research and autoimmune disease management. In B2B contexts, tetrandrine is primarily supplied as a high-purity reagent for pharmaceutical development and academic research. Its multifunctional properties make it a valuable intermediate for drug discovery pipelines targeting cardiovascular and inflammatory conditions.
Physical and Chemical Properties
Tetrandrine appears as a white crystalline solid with a melting point of 217-220°C. It is lipophilic, dissolving readily in organic solvents like chloroform and methanol but exhibiting limited water solubility. The molecule's structure includes two benzylisoquinoline units, contributing to its stability and biological activity. Key chemical properties include its ability to chelate metal ions and inhibit calcium influx in cells, a mechanism underlying its pharmacological effects. Analytical methods such as HPLC and mass spectrometry are commonly employed to assess its purity, which typically exceeds 98% for research applications.
Main Applications
In pharmaceuticals, tetrandrine is investigated for its anti-tumor effects, particularly in multidrug resistance reversal and apoptosis induction. It also shows promise in treating pulmonary fibrosis and rheumatoid arthritis due to its immunosuppressive properties. Traditional medicine utilizes crude extracts for hypertension and edema management. The compound serves as a reference standard in quality control for herbal products and a lead compound in drug design. Industrial buyers often procure it for preclinical studies or as a building block for synthetic derivatives with enhanced bioavailability.
Safety and Storage
Tetrandrine requires careful handling due to its bioactive nature. Laboratory personnel should use PPE (gloves, goggles) to prevent skin contact or inhalation. Acute toxicity studies indicate moderate risk, necessitating adherence to occupational exposure limits. For long-term stability, store the compound in airtight containers under refrigeration (2-8°C) with desiccants to prevent moisture absorption. Degradation products can form under prolonged light exposure, so amber glass vials are recommended. Material Safety Data Sheets (MSDS) must be reviewed prior to large-scale handling.
B2B Procurement Guide
When sourcing tetrandrine, prioritize suppliers with ISO-certified manufacturing facilities and batch-specific Certificates of Analysis (CoA). Key parameters to verify include purity (≥98% by HPLC), residual solvent levels, and endotoxin content for cell culture applications. Bulk buyers should negotiate MOQs (Minimum Order Quantities) and evaluate logistics for temperature-controlled shipping. Pricing varies by purity and scale, with kilogram-scale orders often discounted by 15-30%. Alternative sourcing options include custom synthesis for structural analogs with modified pharmacokinetic profiles.
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