Tetramisole

Updated: 2026-07-15

Overview

Tetramisole is a synthetic compound primarily known for its anthelmintic properties. It was developed in the 1960s and later found to exist as two enantiomers, with the L-form (levamisole) being biologically active. While the racemic mixture (DL-tetramisole) was initially used, levamisole has largely replaced it due to higher efficacy. In veterinary medicine, tetramisole acts as a nicotinic acetylcholine receptor agonist, paralyzing parasitic worms. Its immunomodulatory effects in the L-form also led to limited human medical use, though safety concerns have restricted this application.

Physical and Chemical Properties

Tetramisole is a chiral compound with a molecular weight of 204.29 g/mol and a melting point of 60-62°C. It appears as a white to off-white crystalline powder that is soluble in water and polar organic solvents like ethanol. The racemic DL-form consists of equal parts dextro- and levorotatory enantiomers. Key chemical features include a thiazole ring and an imidazolidine moiety, which contribute to its biological activity. The compound is stable under normal storage conditions but may degrade when exposed to prolonged moisture or extreme pH levels.

Main Applications

The primary use of tetramisole is in veterinary medicine as a broad-spectrum dewormer for livestock, particularly against gastrointestinal nematodes. Its active L-enantiomer, levamisole, is also used in aquaculture and poultry farming. In human medicine, levamisole saw historical use as an immunomodulator for conditions like rheumatoid arthritis and colon cancer adjuvant therapy. However, due to adverse effects (e.g., agranulocytosis), it is now rarely prescribed. Illicit use as a cocaine adulterant has also been reported, posing significant health risks.

Safety and Storage

Tetramisole is moderately toxic, requiring proper handling with gloves, goggles, and respiratory protection to avoid inhalation or skin contact. Acute exposure may cause nausea, dizziness, or seizures. The compound should be stored in airtight containers in a cool, dry place, separate from foodstuffs. Disposal must comply with local environmental regulations due to potential ecological toxicity. Suppliers typically provide Safety Data Sheets (SDS) detailing first-aid measures and spill management procedures.

B2B Procurement Guide

When procuring tetramisole, buyers should prioritize suppliers who provide certificates of analysis (CoA) specifying enantiomeric purity, as levamisole content determines efficacy. Bulk purchases (25kg drums) commonly offer cost savings, with prices varying by purity (typically 98-99.5%). Regulatory compliance is critical; verify that the product meets veterinary or pharmaceutical standards (e.g., USP, EP) for the target market. Spot-checking batches via third-party labs is advisable for large orders.