Overview
Human Tenomodulin (TNMD) is a glycoprotein predominantly found in tendons and ligaments, playing a vital role in their development and maintenance. It is encoded by the TNMD gene and is characterized as a type II transmembrane protein. TNMD is involved in regulating tendon cell differentiation and extracellular matrix organization, making it a key focus in musculoskeletal research. Studies suggest TNMD contributes to tendon strength and elasticity by influencing collagen fibril alignment. Its expression is closely tied to tendon-specific markers, emphasizing its tissue-specific function. Researchers are exploring its potential in regenerative therapies for tendon injuries and degenerative conditions.
Physical and Chemical Properties
TNMD is a glycosylated protein with a molecular weight of approximately 40-50 kDa in its processed form. It consists of an N-terminal cytoplasmic domain, a transmembrane region, and a C-terminal extracellular domain rich in leucine-rich repeats (LRRs). These structural features enable interactions with other extracellular matrix components. The protein is typically supplied as a lyophilized powder or in buffered solutions for research purposes. It is soluble in aqueous buffers but may require optimization for specific experimental conditions. Stability is maintained at low temperatures, with recommended storage at -20°C or below to prevent degradation.
Main Applications
TNMD is primarily utilized in biomedical research to study tendon biology and pathology. Its role in collagen organization makes it a candidate for tissue engineering applications, particularly in developing bioengineered tendons or ligament grafts. Researchers also investigate TNMD as a biomarker for tendon health and disease progression. In the pharmaceutical industry, TNMD is explored for its therapeutic potential in treating tendon injuries, such as tendinopathies or ruptures. Some studies focus on its use in combination with stem cells or growth factors to enhance tendon repair mechanisms.
Safety and Storage
As a research-grade biological material, TNMD should be handled following standard laboratory safety protocols. Use personal protective equipment (PPE) such as gloves and lab coats to avoid direct contact. Proper disposal methods should adhere to institutional guidelines for biological waste. For storage, lyophilized TNMD is stable at -20°C for short-term use, but long-term preservation requires temperatures of -80°C. Reconstituted solutions should be aliquoted to minimize freeze-thaw cycles, which can degrade the protein. Always check the manufacturer’s specifications for stability and shelf-life recommendations.
B2B Procurement Guide
When procuring TNMD for research or commercial use, prioritize suppliers with verified protein purity (≥90%) and biological activity data. Reputable manufacturers often provide certificates of analysis (CoA) detailing endotoxin levels, sterility, and functional assays. Custom production services may be available for large-scale or modified variants. Pricing varies significantly based on purity, quantity, and supplier reputation. Bulk purchases may offer cost savings, but ensure proper storage logistics are in place. For therapeutic applications, compliance with Good Manufacturing Practice (GMP) standards is essential to meet regulatory requirements.
Related Manufacturers
- 主营：增氧剂、消毒液、除雪剂、鱼蛋白、处理剂、消毒剂、硫酸铵、aes洗涤、润湿剂、催化剂、漂白粉、冲施肥、亚硝酸、尿素粉、全水溶、硫酸钠、氧化剂、防霉剂、清洗剂、漂白剂、片水产、洗涤剂、尿素桶、熟石灰、碳酰胺、碳酸钠
- 主营：工业骨胶、工业明胶、牛胶、工业蛋白、蛋白粉、骨胶粉、明胶、皮胶、骨胶、牛胶粉、工业胶、水胶、牛骨胶、小颗粒胶、动物胶
- 主营：胶黏剂、牛皮胶、工业明胶、工业骨胶、胶凝剂颗粒、增稠剂颗粒、木工粘合剂、礼盒粘合胶、木材粘合用胶、冶炼电解牛骨胶、粘性稳定牛骨胶、增稠砂轮用骨胶、墨汁用的牛骨胶、砂轮板材粘合剂、明胶木板胶粘剂
- 主营：人腱调蛋白、ELISA试剂盒、PCR试剂盒、科研试剂
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、人腱调蛋白、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒
- 主营：酶cγ链、α2巨球、素d合成、纤连蛋白、抗组蛋白、蛋白样环、敏感蛋白、蛋白重链、乳球蛋白、蛋白激酶、钙调蛋白、肌醇抗体、牛骨钙素、金属肽酶、钩端螺旋、高血糖素、小鼠α1抗、ELISA试剂盒、pcr检测试剂、生化检测试剂
- 主营：检测方、钠尿肽、试剂盒、结合蛋白、微球蛋白、抗胰蛋白酶、蛋白磷酸酶、核心域蛋白1、激活蛋白激酶、大鼠klotho蛋白、同源物、ep300检测、大鼠c-肽(、淋巴瘤因子、死亡激动剂、大鼠e选择素、大鼠janus激酶、大鼠ⅱ型胶原、大鼠ⅳ型胶原、细胞激活因子、大鼠ⅲ型胶原、大鼠nadh脱氢酶1、大鼠ⅵ型胶原α1、elisa 检测试剂盒
- 主营：人转谷氨酰胺酶、试剂盒、信号调节激酶
- 主营：腱调蛋白、elisa试剂盒
- 主营：大鼠ELISA试剂盒、生化法检测试剂盒、分子学检测试剂盒、人ELISA试剂盒、植物ELISA试剂盒、鱼ELISA试剂盒
- 主营：腱调蛋白、ELISA试剂盒、PCR检测试剂盒、抗体
- 主营：腱调蛋白、elisa试剂盒、检测试剂盒、PCR试剂盒
- 主营：ELISA试剂盒、检测试剂盒、生化试剂盒、pcr检测试剂盒、细胞
- 主营：腱调蛋白、elisa试剂盒
- 主营：试剂盒、胆固醇、褪黑素、脂蛋白、源蛋白、蛋白酶、同源盒、磷酸酶、信号素、整合素、鹦鹉衣、脂肪酶、类固醇、氧化酶、中段肽、羟化酶、凝集素、白三烯、松弛肽、催乳素、肌酸受、白介素、质激素
- 主营：Elisa试剂盒、大鼠elisa试剂盒、小鼠elisa试剂盒、人elisa试剂盒、植物elisa试剂盒、酶联免疫试剂盒
- 主营：ELISA检测试剂盒、检测试剂盒、酶联免疫检测试剂盒、人腱调蛋白、PCR试剂盒
- 主营：elisa试剂盒、生化试剂盒、PCR试剂盒、人腱调蛋白、检测试剂盒、科研试剂盒