Overview
Tegafur is a chemotherapeutic drug primarily used in the treatment of various cancers, including colorectal, gastric, and breast cancers. It is a prodrug of 5-fluorouracil (5-FU), which means it is metabolized in the body to release the active drug. Tegafur is often combined with uracil in a formulation known as UFT (tegafur-uracil) to enhance its therapeutic efficacy by inhibiting the degradation of 5-FU. Developed in the 1970s, tegafur has been widely used in Japan and other Asian countries, though its use has expanded globally. It is valued for its oral bioavailability and relatively milder side effects compared to direct 5-FU administration. However, like all chemotherapy agents, it requires careful handling and monitoring to minimize adverse effects.
Physical and Chemical Properties
Tegafur is a white to off-white crystalline powder with a molecular weight of 200.17 g/mol. It has a melting point range of 169-172°C and is soluble in water and various organic solvents. The compound is stable under recommended storage conditions but should be protected from light and moisture to prevent degradation. The molecular formula of tegafur is C8H9FN2O3, and it belongs to the fluoropyrimidine class of compounds. Its chemical structure includes a tetrahydrofuran ring, which contributes to its prodrug properties. The fluorine atom at the 5-position of the pyrimidine ring is critical for its antineoplastic activity, as it interferes with DNA and RNA synthesis in cancer cells.
Main Applications
Tegafur is primarily used in oncology for the treatment of colorectal, gastric, and breast cancers. It is often administered as part of combination therapies, such as UFT (tegafur-uracil), which enhances the bioavailability and efficacy of the active metabolite, 5-FU. This combination is particularly effective in adjuvant and palliative settings. In addition to its use in monotherapy, tegafur is sometimes combined with other chemotherapeutic agents or radiation therapy to improve treatment outcomes. Its oral formulation makes it a convenient option for outpatient treatment, reducing the need for hospital visits. However, its use must be carefully monitored due to potential side effects, including myelosuppression and gastrointestinal toxicity.
Safety and Storage
Tegafur is a potent chemotherapeutic agent and should be handled with care to avoid exposure. Appropriate personal protective equipment (PPE), such as gloves and lab coats, should be worn when handling the compound. It should be stored in a cool, dry place, away from light and moisture, to maintain its stability. In clinical settings, tegafur is administered under strict medical supervision due to its potential side effects, which may include nausea, vomiting, diarrhea, and myelosuppression. Patients should be monitored regularly for adverse reactions, and dosage adjustments may be necessary based on individual tolerance and response. Proper disposal methods should be followed to prevent environmental contamination.
B2B Procurement Guide
When procuring tegafur for B2B purposes, it is essential to verify the supplier's compliance with pharmaceutical standards and certifications, such as Good Manufacturing Practice (GMP). The reference price range is approximately $50-$100 per gram, depending on purity and supplier. Bulk purchases may offer cost advantages, but quality should not be compromised. Procurement professionals should also consider the supplier's reliability, lead times, and ability to provide necessary documentation, such as Certificates of Analysis (CoA). Due to the sensitive nature of the compound, logistics and storage conditions during transportation should be carefully planned to ensure product integrity. Building long-term relationships with reputable suppliers can help secure consistent quality and availability.
Related Manufacturers
- 主营：甘氨酸、溴化物、蒽甲酸、紫苏葶、锂电池、牛磺酸、褪黑素、磷酸铟、新癸酸、赖氨酸、溴化鏻、乙氧基、藏花醛、豆甾醇、羟乙基、维素酶、庚二酸、呋虫胺、丹参素、萘甲醛、槐豆胶、黄柏酮、元明粉、乙氨基、1-(2-(4-(