Overview
Taraxasteryl acetate is a naturally occurring phytosterol ester derived from plants like Taraxacum officinale (dandelion). As a modified sterol compound, it combines the biological activity of taraxasterol with improved stability through acetylation. This compound has gained attention in both pharmaceutical research and cosmetic science due to its unique structural properties and biological effects. The substance is typically synthesized through the esterification of taraxasterol with acetic anhydride. Industrial production involves purification steps to achieve pharmaceutical-grade purity (typically ≥95%). Its molecular structure features a tetracyclic sterol backbone with an acetyl group at the 3β-position, which enhances its lipophilicity and bioavailability compared to the parent taraxasterol.
Physical and Chemical Properties
Taraxasteryl acetate presents as a crystalline solid with moderate thermal stability, maintaining structural integrity up to its melting point around 180-185°C. The acetyl group significantly increases its solubility in organic solvents compared to non-esterified sterols, making it particularly suitable for formulation in lipid-based delivery systems. Spectroscopic characterization typically shows distinctive peaks in infrared spectroscopy (C=O stretch at ~1740 cm⁻¹) and nuclear magnetic resonance (NMR) spectra (acetyl methyl protons at ~2.0 ppm). The compound demonstrates stability under neutral pH conditions but may undergo hydrolysis in strongly acidic or alkaline environments. Its logP value (approximately 7-8) indicates high lipophilicity, influencing its penetration characteristics in biological systems.
Main Applications
In pharmaceutical applications, taraxasteryl acetate serves as an intermediate for steroid synthesis and as an active ingredient in topical formulations targeting inflammatory skin conditions. Research suggests it modulates inflammatory pathways by inhibiting NF-κB activation, making it valuable for dermatological preparations. The cosmetic industry utilizes this compound primarily in skincare products for sensitive or irritated skin. It functions as both an active ingredient (providing anti-inflammatory and barrier-repair benefits) and a formulation stabilizer. Common applications include after-sun products, anti-redness creams, and formulations for conditions like eczema or psoriasis. Some manufacturers incorporate it into anti-aging products for its potential collagen-stimulating effects.
Safety and Storage
Toxicological studies classify taraxasteryl acetate as low-risk for topical application, with no significant irritation observed at typical use concentrations (0.1-2%). However, appropriate personal protective equipment (gloves, eye protection) is recommended during industrial handling to prevent dust exposure. Proper storage requires protection from oxidation and moisture absorption. The material should be kept in sealed containers with desiccants, ideally under refrigerated conditions (2-8°C) for long-term preservation. Under these conditions, shelf life typically exceeds 24 months. Quality control should include periodic checks for signs of hydrolysis (free acetic acid detection) and color changes indicating oxidation.
B2B Procurement Guide
When sourcing taraxasteryl acetate, buyers should prioritize suppliers who provide comprehensive analytical certificates (CoA) including HPLC purity profiles, residual solvent analysis, and heavy metal content. Pharmaceutical-grade material should comply with relevant pharmacopeia standards (USP/EP/JP) where applicable. Batch-to-batch consistency is crucial, particularly for cosmetic formulators requiring stable emulsion properties. Request samples for compatibility testing with your base formulations. For large-volume purchases (100+ kg), consider suppliers with GMP-certified production facilities. Market prices fluctuate based on raw material availability (particularly dandelion extract supply) and purity specifications, with bulk discounts typically available at the 25kg+ quantity tier.
Related Manufacturers
- 主营：单磷酸、白果酸、银杏酸、白术内酯、澳洲茄胺、红四氮唑、白当归脑、曲氟胸苷、安石榴苷、二磷酸葡、四氮唑蓝、澳洲茄碱、巴卡亭iii、白藜芦醇、脱氧尿苷、澳洲茄边、白当归素、脱氧腺苷、腺苷一水合、二磷酸钠盐、白花前胡丙、羟甲香豆素、尿苷三磷酸、菝葜皂苷元、磷酸二钠盐
- 主营：吴茱萸、儿茶素、丹参酮、蒲公英甾醇乙酸酯、石竹素、熊果酸、柚皮素、咖啡酸、刺蒺藜、柚皮苷、花青素、根皮素、橙皮素、葛根素、耙齿菌、芍药苷、甘草酸、浓缩粉、水杨苷、虎杖苷、根皮苷、栀子苷、利血平、西瓜粉、大黄苷、槐果碱
- 主营：对照品、标准品、三叶苷、蒲公英甾醇乙酸酯、姜烯酚、人参皂苷、地黄苷、科研试剂、实验室自制、生育三烯酚
- 主营：蒲公英甾醇乙酸酯、白僵菌素、薯蓣皂苷
- 主营：标准品、细辛脂素、百两金素、延胡索乙素、桃叶珊瑚苷、脱氢紫堇碱
- 主营：甘草醇、环黄芪苷、异甘草素、蒲公英甾醇乙酸酯、甘草甜素、黄芪皂苷、甘草次酸、黄芪甲苷、异甘草苷、芒柄花黄素、黄芪总皂甙、甘草酸单铵盐
- 主营：芍药素、花姜酮、氨基辛酸、蒲公英甾醇乙酸酯、飞燕草素、天竺葵素、矮牵牛素、葡萄糖苷、半乳糖苷、阿拉伯糖苷、天竺葵色素、去氢钩藤碱、氯化锦葵色素
- 主营：标准品、中药对照品、槲皮万寿菊素、蒲公英甾醇乙酸酯、新绿原酸
- 主营：树脂酮、杨梅醇、毛兰素、蒲公英、大戟醇、熊果醛、洋艾素、二氢菲、茯苓酸、罗汉果、钩藤碱、槲皮素、树脂素、标准品、艾奇酸、乌发醇、苦瓜素、对照品、酒渣碱、齐墩果醛、葡萄糖苷、白色粉末、至纯本草、阿里二醇、款冬二醇、碱盐酸盐
- 主营：桤木酮、淫羊藿、皂苷bii、蒲公英甾醇乙酸酯、泽泻醇、香附酮、棕榈碱、羟苯基、半乳糖、山酮iii、甘草酚、侧柏酮、精氨酸、佛尔酮、维生素、管花苷、虫草素、对照品、利卡灵、卵磷脂、大豆苷、姜黄素、黄烷酮、半合成、苹果酸、三羟基
- 主营：蒲公英甾醇乙酸酯、香精香料化妆品、中药对照品