Overview
Sphingosine is a fundamental 18-carbon amino alcohol and a core component of sphingolipids, a class of lipids critical to eukaryotic cell membranes. It serves as a biosynthetic precursor for ceramides and other complex sphingolipids, which regulate cellular processes like apoptosis, proliferation, and inflammation. Discovered in the 19th century, sphingosine derives its name from the Sphinx due to its enigmatic role in early biochemical studies. Today, it is synthesized both naturally in organisms and industrially for research and commercial applications.
Physical and Chemical Properties
Sphingosine is characterized by its amphiphilic structure, featuring a polar head group (amino and hydroxyl groups) and a non-polar hydrocarbon tail. This duality enables it to integrate into lipid bilayers and interact with both aqueous and lipid environments. Its crystalline form is stable under recommended storage conditions but may degrade upon prolonged exposure to light or humidity. The compound’s solubility profile dictates its use in organic solvents for laboratory preparations, while its melting point ensures stability at room temperature for short-term handling.
Main Applications
In pharmaceuticals, sphingosine is studied for its role in cancer therapy, particularly in modulating ceramide pathways to induce apoptosis in tumor cells. It is also explored in immunology for its influence on inflammatory responses. The cosmetic industry utilizes sphingosine derivatives (e.g., ceramides) in skincare products to enhance moisture retention and repair the skin barrier. Its anti-aging and protective properties make it a sought-after ingredient in high-end formulations.
Safety and Storage
As a bioactive lipid, sphingosine requires careful handling to prevent degradation or contamination. Lab personnel should use gloves and goggles, and work in well-ventilated areas to avoid respiratory irritation. Long-term storage demands airtight, light-resistant containers at sub-zero temperatures (-20°C or lower) with desiccants to mitigate moisture absorption. Bulk shipments often require temperature-controlled transport to preserve integrity.
B2B Procurement Guide
B2B buyers should prioritize suppliers with ISO certification and detailed COAs (Certificates of Analysis) specifying purity (HPLC-verified ≥98% for research-grade). Batch-specific documentation ensures traceability. For large-scale orders, negotiate logistics for cold-chain delivery and consider regional warehouses to minimize transit time. Spot-checking upon receipt is advised to confirm compliance with specifications.
Related Manufacturers
- 主营：四乙酰植物鞘氨醇、桉脂素、化学试剂、β-香树脂酮
- 主营：植物鞘氨醇、对照品、标准品
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、磷酸鞘氨醇受体ELISAKit、蛋白、抗体、细胞、检测试剂盒
- 主营：人鞘氨醇激酶2、ELISA试剂盒、PCR试剂盒、科研试剂
- 主营：elisa 试剂盒、Elisa试剂盒、进口试剂盒、磷酸鞘氨醇ELISA试剂盒、国产试剂盒、试剂、细胞、ELISA检测试剂盒、酶联免疫法、酶联免疫试剂盒、酶活性检测、酶标仪检测
- 主营：试剂盒、人25羟基维生素、人低氧诱导因子
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、小鼠鞘氨醇激酶、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、小鼠鞘氨醇激酶、生化试剂盒、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒
- 主营：试剂盒、elisa试剂盒、细胞、pcr试剂盒
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、鞘氨醇激酶1ELISA试剂盒、蛋白、抗体、细胞
- 主营：ELISA试剂盒、抗体
- 主营：花生酸、碳酸钠、单氟磷酸钠、丁基羟基茴香醚、鱼大豆酵母原料
- 主营：酶cγ链、α2巨球、素d合成、人鞘氨醇激酶1elisaKit、纤连蛋白、抗组蛋白、肌醇抗体、蛋白样环、敏感蛋白、牛骨钙素、蛋白重链、金属肽酶、乳球蛋白、钩端螺旋、蛋白激酶、高血糖素、钙调蛋白、小鼠α1抗、ELISA试剂盒、pcr检测试剂、生化检测试剂
- 主营：检测方、钠尿肽、试剂盒、同源物、ep300检测、结合蛋白、大鼠c-肽(、微球蛋白、抗胰蛋白酶、淋巴瘤因子、蛋白磷酸酶、死亡激动剂、核心域蛋白1、大鼠e选择素、大鼠janus激酶、激活蛋白激酶、大鼠ⅱ型胶原、大鼠ⅳ型胶原、大鼠klotho蛋白、细胞激活因子、大鼠ⅲ型胶原、大鼠nadh脱氢酶1、大鼠ⅵ型胶原α1、elisa 检测试剂盒