Overview
Bovine Brain Sphingomyelin is a sphingophospholipid naturally found in the myelin sheath of nerve cells, extracted from bovine brain tissue. It consists of a sphingosine backbone, a fatty acid chain, and a phosphocholine head group. This lipid is essential for cellular membrane integrity and signaling pathways. Its unique structure makes it valuable for studying membrane dynamics and lipid rafts in biomedical research. In industrial applications, sphingomyelin is used as an emulsifier in cosmetics and a component in liposomal drug delivery systems. Due to its origin, ethical sourcing and quality control are critical considerations for B2B buyers.
Physical and Chemical Properties
Bovine Brain Sphingomyelin is a white to off-white powder with a molecular weight of 731.09 g/mol. It decomposes at temperatures around 200-210°C without a distinct boiling point. The compound is amphipathic, meaning it has both hydrophilic (phosphocholine head) and hydrophobic (sphingosine and fatty acid tail) regions. Its solubility profile includes organic solvents like chloroform, methanol, and ethanol, but it is insoluble in water. In aqueous environments, it spontaneously forms bilayers or micelles, mimicking biological membranes. These properties are exploited in research to model cell membranes and study lipid-protein interactions.
Main Applications
In biochemistry and neuroscience, Bovine Brain Sphingomyelin is used to investigate membrane structure, lipid rafts, and signal transduction mechanisms. Its role in myelin sheath formation makes it relevant for studying neurodegenerative diseases like multiple sclerosis. The pharmaceutical industry utilizes sphingomyelin in liposomal formulations for targeted drug delivery, enhancing the stability and bioavailability of therapeutic agents. In cosmetics, it acts as a skin-conditioning agent, improving moisture retention and barrier function in creams and serums.
Safety and Storage
While Bovine Brain Sphingomyelin is non-toxic, proper handling is essential to avoid contamination. Use gloves and safety goggles when handling the powder, and work in a well-ventilated area. Long-term exposure to moisture or light can degrade the compound, leading to reduced efficacy. Storage at -20°C in an airtight, light-protected container is recommended. For laboratory use, aliquot smaller quantities to minimize repeated thawing. Always refer to the Material Safety Data Sheet (MSDS) for specific hazard and disposal guidelines.
B2B Procurement Guide
When procuring Bovine Brain Sphingomyelin, prioritize suppliers with certifications (e.g., ISO, GMP) to ensure traceability and quality. Key specifications include purity (≥98%), low endotoxin levels, and absence of solvents. Request a Certificate of Analysis (COA) to validate these parameters. Bulk pricing is typically negotiable for orders above 10 grams. Lead times may vary due to the specialized extraction process. For cosmetic or pharmaceutical use, confirm compliance with regulatory standards (e.g., FDA, EU Cosmetics Regulation). Consider alternative sources like synthetic sphingomyelin if ethical sourcing is a concern.
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