Overview
Disodium α-Ketoglutarate (α-KG) is the sodium salt of α-ketoglutaric acid, a crucial intermediate in the Krebs cycle, which is central to cellular energy production. It is widely utilized in pharmaceuticals, dietary supplements, and food industries due to its metabolic benefits. The compound is synthesized through chemical processes that ensure high purity for various applications. α-KG plays a vital role in amino acid synthesis and nitrogen transport, making it indispensable in biochemical research and medical therapies. Its ability to enhance energy metabolism has also led to its use in sports nutrition and health supplements.
Physical and Chemical Properties
Disodium α-Ketoglutarate appears as a white crystalline powder with high solubility in water, making it easy to incorporate into liquid formulations. It decomposes at temperatures around 135-140°C, and its molecular weight is 190.06 g/mol. The compound is stable under normal storage conditions but should be protected from moisture and extreme temperatures. Its chemical structure includes a ketone group and two carboxylate groups, which contribute to its reactivity and role in metabolic pathways. The high solubility and stability of α-KG make it suitable for a wide range of industrial and laboratory applications.
Main Applications
In the pharmaceutical industry, Disodium α-Ketoglutarate is used in formulations aimed at improving energy metabolism and treating metabolic disorders. It is also a popular ingredient in dietary supplements designed to enhance athletic performance and recovery. The food industry employs α-KG as a flavor enhancer and preservative due to its mild acidic properties. Biochemical research utilizes α-KG as a substrate for enzymes involved in the Krebs cycle and amino acid metabolism. Its role in cellular energy production and nitrogen balance makes it a valuable tool in studying metabolic diseases and developing therapeutic interventions.
Safety and Storage
Disodium α-Ketoglutarate is generally regarded as safe for use in pharmaceuticals and food products. However, prolonged exposure to the powder should be avoided to prevent respiratory irritation. Proper storage in a cool, dry place away from direct sunlight ensures the compound's stability and longevity. Safety data sheets recommend using personal protective equipment, such as gloves and masks, when handling large quantities. In case of accidental ingestion or contact with eyes, rinse immediately with water and seek medical advice if irritation persists.
B2B Procurement Guide
When procuring Disodium α-Ketoglutarate, it is essential to verify the purity grade, especially for pharmaceutical and research applications. Suppliers should provide certificates of analysis (CoA) to confirm the product's specifications. Bulk buyers should also consider the supplier's reputation and compliance with Good Manufacturing Practices (GMP). Price negotiations should factor in the desired purity level, with pharmaceutical-grade α-KG typically commanding a higher price. Long-term contracts with reliable suppliers can ensure consistent quality and favorable pricing, while also reducing procurement risks.
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