Overview
Sodium dehydrocholate is a synthetic bile acid derivative derived from dehydrocholic acid. It is widely used in the pharmaceutical industry due to its choleretic properties, which stimulate bile production. The compound is also employed in diagnostic tests to assess liver function. Originally developed as a therapeutic agent, sodium dehydrocholate has found niche applications in medical research and diagnostics. Its solubility in water and ethanol makes it suitable for intravenous administration in clinical settings.
Physical and Chemical Properties
Sodium dehydrocholate appears as a white to off-white crystalline powder with a molecular weight of 424.51 g/mol. It decomposes at approximately 230-235°C and is highly soluble in water and ethanol, though only slightly soluble in ether. The compound's choleretic activity stems from its ability to increase bile flow without significantly altering bile composition. This property makes it valuable for liver function tests and certain therapeutic applications where bile secretion stimulation is required.
Main Applications
The primary use of sodium dehydrocholate is in the pharmaceutical industry as a choleretic agent. It is commonly included in liver function diagnostic tests to measure the liver's excretory capacity. In research settings, sodium dehydrocholate serves as a reference standard for bile acid studies. Some medical formulations use it to promote bile flow in patients with specific hepatic conditions, though its therapeutic use has declined with newer alternatives.
Safety and Storage
Sodium dehydrocholate requires careful handling with appropriate personal protective equipment (PPE), including gloves and eye protection. While not classified as highly hazardous, inhalation or direct contact should be avoided. The compound should be stored in tightly sealed containers in a cool, dry environment protected from light and moisture. Proper storage conditions help maintain stability and prevent degradation of the crystalline powder.
B2B Procurement Guide
When procuring sodium dehydrocholate, buyers should prioritize suppliers who provide comprehensive product specifications, including purity levels (typically ≥98%) and detailed certificates of analysis. Request batch-specific testing reports to verify quality and consistency. Pharmaceutical-grade material should meet relevant pharmacopeia standards (e.g., USP, EP). Consider lead times and minimum order quantities, as this is a specialty chemical with limited production volumes compared to commodity chemicals.
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