Overview
Norcantharidin Sodium is a synthetic derivative of cantharidin, a compound originally derived from blister beetles. It was developed to retain the antitumor properties of cantharidin while reducing its toxicity. This compound has gained attention in oncology research due to its ability to inhibit tumor cell proliferation and induce apoptosis. Unlike its parent compound, Norcantharidin Sodium exhibits lower nephrotoxicity, making it a safer candidate for clinical applications. It is commonly used in traditional Chinese medicine and modern pharmaceutical research, particularly in studies targeting liver, gastric, and esophageal cancers.
Physical and Chemical Properties
Norcantharidin Sodium appears as a white to off-white crystalline powder with high thermal stability, decomposing only above 300°C. It is highly soluble in water, which facilitates its use in injectable formulations, and slightly soluble in ethanol. The compound is stable under standard storage conditions but may degrade upon prolonged exposure to light or moisture. The molecular structure of Norcantharidin Sodium includes two sodium ions, which enhance its solubility and bioavailability. Its low molecular weight (232.15 g/mol) allows for efficient cellular uptake, contributing to its pharmacological activity.
Main Applications
The primary application of Norcantharidin Sodium is in cancer therapy, where it is used to inhibit the growth of various tumor types. It has shown efficacy in hepatocellular carcinoma, leukemia, and colorectal cancer by disrupting cell cycle progression and promoting apoptosis. Clinically, it is often administered via injection or oral formulations. Beyond oncology, Norcantharidin Sodium is employed as a research reagent to study cell signaling pathways and angiogenesis. Its ability to modulate protein phosphatases makes it a valuable tool in biochemical research, particularly in investigating tumor metastasis and drug resistance mechanisms.
Safety and Storage
While Norcantharidin Sodium is less toxic than cantharidin, it should still be handled with care. Direct contact with skin or eyes may cause irritation, and inhalation of dust should be avoided. Proper personal protective equipment (PPE), including gloves and goggles, is recommended during handling. The compound should be stored in a tightly sealed container in a cool, dry place, protected from light and moisture. Long-term storage under suboptimal conditions may lead to degradation, reducing its efficacy. For laboratory or industrial use, ensure compliance with local regulations for hazardous chemical storage.
B2B Procurement Guide
When procuring Norcantharidin Sodium for pharmaceutical or research purposes, prioritize suppliers with certifications such as GMP or ISO 9001. Verify the purity (typically ≥98%) through independent testing or certificates of analysis (CoA). Bulk purchases may qualify for discounts, but ensure the supplier can meet consistent quality standards. Consider logistical factors such as shipping conditions (e.g., temperature-controlled transport for large quantities) and lead times. For international procurement, confirm that the supplier complies with export/import regulations, including necessary documentation like Material Safety Data Sheets (MSDS).
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