Overview
Shizukanolide is a bioactive sesquiterpene lactone isolated from Chloranthus japonicus (commonly known as 银线草). First identified in the 1980s, it belongs to a class of compounds with demonstrated pharmacological potential, particularly in anti-inflammatory and anticancer research. Its unique molecular structure, featuring a γ-lactone ring, contributes to its biological activity. In traditional East Asian medicine, extracts from Chloranthus species have been used for pain relief and wound healing. Modern studies focus on shizukanolide's mechanism of action, including its ability to modulate NF-κB signaling pathways, which are implicated in inflammatory diseases.
Physical and Chemical Properties
Shizukanolide crystallizes as a white powder with a melting point range of 120-123°C. Its molecular weight of 248.32 g/mol and lipophilic nature (logP ~2.5) make it soluble in polar organic solvents but nearly insoluble in water. The compound is stable under inert conditions but may degrade upon prolonged exposure to UV light or humidity. Spectroscopic analysis (NMR, IR) confirms the presence of characteristic functional groups, including an α,β-unsaturated γ-lactone moiety responsible for its reactivity. The CAS registry (94367-42-7) ensures precise identification for procurement and regulatory compliance.
Main Applications
Shizukanolide is primarily investigated for its therapeutic potential. Research highlights its cytotoxicity against certain cancer cell lines (e.g., HepG2, MCF-7) at micromolar concentrations, suggesting possible applications in oncology drug development. Its anti-inflammatory effects are attributed to the inhibition of pro-inflammatory cytokines like TNF-α and IL-6. Beyond pharmaceuticals, the compound serves as a reference standard in phytochemical analysis. Laboratories use it to authenticate Chloranthus extracts or study structure-activity relationships among sesquiterpene lactones. Industrial demand is niche but growing, driven by natural product research.
Safety and Storage
As a bioactive compound, shizukanolide requires careful handling. Laboratory safety protocols mandate gloves, goggles, and fume hoods to prevent skin/eye contact or inhalation of dust. Although acute toxicity data are limited, structural analogs suggest potential irritant effects. Proper storage involves airtight containers with desiccants, maintained at 2-8°C to prevent degradation. Long-term stability testing indicates minimal decomposition when protected from light. Material Safety Data Sheets (MSDS) should be consulted before use, especially for bulk quantities in industrial settings.
B2B Procurement Guide
Procuring shizukanolide requires attention to purity and supplier credibility. Research-grade material typically commands $50-$200 per milligram, with prices scaling for bulk orders (≥1 gram). HPLC certificates (≥98% purity) and NMR spectra are essential quality indicators. Specialized phytochemical suppliers or custom synthesis providers are preferred sources. Buyers should confirm CAS number alignment and request batch-specific COAs (Certificates of Analysis). Due to limited commercial availability, lead times may extend to 4-8 weeks. Consider cold-chain logistics for international shipments to preserve stability.
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