Overview
Scutellarin is a bioactive flavonoid glycoside primarily extracted from plants of the Scutellaria genus, notably Scutellaria baicalensis. It is a major active component in traditional Chinese medicine (TCM) formulations like Huang Qin, valued for its therapeutic properties. Modern research highlights its potential in treating cardiovascular and neurological disorders due to its antioxidant and anti-inflammatory effects. In industrial applications, scutellarin is used in pharmaceuticals, dietary supplements, and cosmetic formulations. Its stability and bioavailability are key considerations for manufacturers. The compound is typically synthesized or extracted via advanced purification techniques to ensure high purity and efficacy.
Physical and Chemical Properties
Scutellarin is a yellow crystalline powder with a molecular weight of 462.36 g/mol. It is soluble in organic solvents like methanol and ethanol but has limited solubility in water. The compound exhibits a melting point of 218-220°C, making it stable under typical processing conditions. Its chemical structure includes a glucuronide moiety attached to scutellarein, enhancing its bioavailability. The flavonoid backbone contributes to its strong UV absorption, useful for analytical quantification via HPLC. Stability tests indicate scutellarin degrades under prolonged exposure to light or high humidity, necessitating controlled storage.
Main Applications
In pharmaceuticals, scutellarin is used to develop drugs for cerebrovascular diseases, such as ischemic stroke, due to its neuroprotective effects. It is also studied for its potential in reducing oxidative stress and inflammation in chronic conditions like diabetes and atherosclerosis. The nutraceutical industry incorporates scutellarin into health supplements targeting cognitive function and cardiovascular health. In cosmetics, it is added to anti-aging formulations for its antioxidant properties. Traditional medicine continues to use scutellarin-rich extracts in herbal remedies, often combined with other bioactive compounds for synergistic effects.
Safety and Storage
Scutellarin is classified as low-toxicity, with no significant adverse effects reported at standard dosages. However, occupational safety measures, such as gloves and goggles, are recommended during handling to avoid inhalation or skin contact. Always refer to the SDS for specific guidelines. For storage, keep the compound in airtight containers under inert gas (e.g., nitrogen) to prevent oxidation. Optimal conditions include temperatures below 25°C and relative humidity under 60%. Bulk quantities should be stored in climate-controlled warehouses with limited light exposure to preserve stability.
B2B Procurement Guide
When procuring scutellarin, prioritize suppliers with ISO or GMP certifications to ensure quality compliance. Request certificates of analysis (CoA) detailing purity (≥98% by HPLC), residual solvents, and heavy metal content. Batch-specific testing is critical for pharmaceutical-grade purchases. Pricing varies based on quantity and purity; bulk orders (1 kg+) often reduce costs by 20-30%. Lead times depend on supplier inventory, with custom synthesis requiring 4-8 weeks. Consider logistics: scutellarin is non-hazardous but may require temperature-controlled shipping for international transport.
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