Scopolamine Hydrobromide

Updated: 2026-09-20

Overview

Scopolamine Hydrobromide is a tropane alkaloid derived from plants of the Solanaceae family. It is widely used in medicine for its anticholinergic properties, which help to block the action of acetylcholine in the nervous system. This compound is particularly effective in managing motion sickness and nausea, making it a staple in both clinical and over-the-counter applications. The pharmacological effects of Scopolamine Hydrobromide include sedation, reduction of gastrointestinal motility, and inhibition of secretions. Its ability to cross the blood-brain barrier allows it to exert central nervous system effects, which are beneficial in treating vertigo and other vestibular disorders.

Physical and Chemical Properties

Scopolamine Hydrobromide is a white crystalline powder with a molecular weight of 438.31 g/mol. It is soluble in water and alcohol, which facilitates its formulation into various pharmaceutical preparations such as tablets, injections, and transdermal patches. The compound has a melting point of approximately 195-198°C, indicating its stability under normal storage conditions. The chemical structure of Scopolamine Hydrobromide includes a tropane ring, which is characteristic of many anticholinergic drugs. This structure is responsible for its ability to bind to muscarinic acetylcholine receptors, thereby inhibiting parasympathetic nerve impulses. The hydrobromide salt form enhances its solubility and bioavailability, making it more effective for therapeutic use.

Main Applications

Scopolamine Hydrobromide is primarily used to prevent and treat motion sickness, a condition characterized by nausea and vomiting during travel. It is also employed postoperatively to manage nausea and vomiting caused by anesthesia or surgical procedures. Additionally, the compound has been investigated for its potential use in treating irritable bowel syndrome and other gastrointestinal disorders. In clinical settings, Scopolamine Hydrobromide is administered via oral tablets, subcutaneous injections, or transdermal patches. The transdermal patch is particularly popular for its convenience and prolonged release of the drug, providing up to 72 hours of relief from motion sickness symptoms.

Safety and Storage

Scopolamine Hydrobromide should be stored in a cool, dry place, protected from light and moisture to maintain its stability. Proper storage conditions are essential to prevent degradation of the compound, which could reduce its efficacy. The drug should be kept out of reach of children and pets due to its potent pharmacological effects. Safety precautions include avoiding use in patients with glaucoma, urinary retention, or other conditions exacerbated by anticholinergic drugs. Side effects may include dry mouth, blurred vision, dizziness, and drowsiness. Healthcare providers should monitor patients for signs of anticholinergic toxicity, especially in elderly individuals or those with pre-existing medical conditions.

B2B Procurement Guide

When procuring Scopolamine Hydrobromide for B2B purposes, it is crucial to verify the supplier's adherence to pharmaceutical-grade standards and regulatory requirements. Buyers should request certificates of analysis (CoA) to ensure the purity and potency of the compound. Additionally, consider the supplier's reputation, lead times, and ability to provide consistent quality. Price negotiations should take into account the quantity ordered, with bulk purchases often resulting in cost savings. However, prioritize quality and compliance over price to avoid substandard products. Establish long-term relationships with reliable suppliers to ensure a steady and dependable supply chain for this essential pharmaceutical ingredient.