Overview
Schaftoside Reference Standard is a purified flavonoid glycoside primarily used as a quality control benchmark in pharmaceutical and herbal medicine industries. It is isolated from plants such as Scutellaria baicalensis (Chinese skullcap) and serves as a critical tool for validating analytical methods like HPLC and LC-MS. As a certified reference material (CRM), it ensures accuracy in quantifying schaftoside content in raw materials and finished products. Its standardized properties make it indispensable for regulatory compliance, particularly in traditional Chinese medicine (TCM) research and manufacturing.
Physical and Chemical Properties
Schaftoside is characterized by its molecular formula C26H28O14 and a molar mass of 564.49 g/mol. The compound typically presents as a white to off-white crystalline powder with a melting point around 190-195°C (with decomposition). It exhibits good solubility in polar organic solvents like methanol and DMSO but has limited solubility in water. Its chemical stability is maintained when stored under recommended conditions (2-8°C, protected from light and moisture). Spectroscopic properties, including UV-Vis absorption maxima, are well-documented for analytical method development. The compound’s purity is typically verified via HPLC, with commercial standards often exceeding 98% purity.
Main Applications
The primary use of schaftoside reference standard is in analytical laboratories for method validation and quality assurance. It is essential for calibrating instruments and quantifying schaftoside levels in herbal extracts, TCM formulations, and nutraceuticals. In pharmaceutical research, it aids in pharmacokinetic studies and bioavailability assessments. The compound also serves as a marker for authentication of Scutellaria species and other medicinal plants. Recent studies explore its potential bioactive properties, including anti-inflammatory and antioxidant effects, though these applications remain investigational.
Safety and Storage
Schaftoside reference standard is classified as low-risk under normal laboratory handling conditions. However, standard precautions include wearing gloves and avoiding inhalation of powder. No significant toxicity data are reported, but workplace exposure limits should follow general chemical safety guidelines. Proper storage requires refrigeration (2-8°C) in tightly sealed, light-resistant containers to prevent degradation. Long-term stability is ensured by minimizing temperature fluctuations and humidity exposure. Shipping typically involves cold packs for temperature-sensitive batches.
B2B Procurement Guide
When procuring schaftoside reference standard, prioritize suppliers with ISO 17034 accreditation for reference materials. Key documentation includes a Certificate of Analysis (COA) detailing purity (HPLC ≥98%), batch number, and expiration date. Analytical chromatograms should accompany the product. Bulk purchases (gram-scale) may require advance notice due to limited inventory. Compare lead times and pricing from specialized phytochemical suppliers. For regulatory submissions, ensure the standard meets pharmacopoeial requirements (e.g., USP, EP) if applicable. Consider supplier technical support for method development assistance.
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