RSL3
Overview
RSL3 is a synthetic compound classified as a ferroptosis inducer, specifically inhibiting glutathione peroxidase 4 (GPX4). Discovered for its selective lethality in RAS-mutated cancer cells, it has become a pivotal tool in studying oxidative cell death pathways. Researchers value RSL3 for its ability to trigger lipid peroxidation, a hallmark of ferroptosis. Its mechanism involves depleting cellular antioxidant defenses, making it valuable for investigating cancer vulnerabilities and therapeutic strategies.
Physical and Chemical Properties
RSL3 is a light yellow solid with a molecular weight of 411.91 g/mol. It is soluble in organic solvents like DMSO, methanol, and ethanol but has limited solubility in aqueous buffers. The compound's stability depends on proper storage at -20°C in anhydrous conditions. Its reactivity with GPX4 is central to its function, involving covalent binding to the enzyme's active site selenium moiety.
Main Applications
RSL3 is predominantly used in oncology research to study ferroptosis-dependent cancer cell death. It helps identify tumors susceptible to oxidative stress, particularly those with RAS mutations or GPX4 dependencies. Beyond cancer, RSL3 aids in exploring neurodegenerative diseases and ischemia-reperfusion injury, where ferroptosis plays a role. Pharmaceutical companies utilize it in high-throughput screening for GPX4-targeting drug candidates.
Safety and Storage
RSL3 requires careful handling due to its reactive nature. Use personal protective equipment (PPE) and work in a ventilated hood to avoid inhalation or skin contact. For long-term stability, store aliquots at -20°C in tightly sealed, light-resistant vials with desiccants. Avoid repeated freeze-thaw cycles to prevent degradation.
B2B Procurement Guide
When sourcing RSL3, prioritize suppliers specializing in research chemicals with certificates of analysis (CoA). Key specifications include ≥98% purity (HPLC) and batch-specific NMR/LC-MS data. Bulk purchases (e.g., 50-100 mg) may offer cost savings but require validation of storage infrastructure. Consider vendors compliant with ISO 9001 or GMP standards for consistent quality.
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