Overview
Rotundic acid is a bioactive triterpenoid compound extracted from the bark of Ilex rotunda, a plant commonly used in traditional Chinese medicine. It has gained attention for its pharmacological properties, including anti-inflammatory, hepatoprotective, and antioxidant effects. The compound is structurally classified as a pentacyclic triterpene and is often standardized for use in herbal formulations and modern pharmaceuticals. Research into rotundic acid has highlighted its potential in treating liver diseases, reducing oxidative stress, and modulating immune responses. Its natural origin and therapeutic profile make it a valuable ingredient in both traditional remedies and evidence-based medicine. The compound is typically isolated through solvent extraction and chromatographic purification.
Physical and Chemical Properties
Rotundic acid is a white to off-white crystalline powder with a molecular weight of 486.69 g/mol. It has a melting point of approximately 220-225°C and is soluble in organic solvents like methanol and ethanol, but only slightly soluble in water. These properties influence its extraction and formulation processes, often requiring solubility enhancers for aqueous applications. The compound's stability is affected by light and moisture, necessitating storage in airtight containers under controlled conditions. Its triterpenoid structure contributes to its biological activity, particularly its ability to interact with cellular pathways involved in inflammation and oxidative stress. Analytical methods such as HPLC are used to assess its purity, which is critical for pharmaceutical applications.
Main Applications
Rotundic acid is primarily used in the pharmaceutical and nutraceutical industries. In traditional Chinese medicine, it is incorporated into formulations for liver protection and detoxification. Modern research explores its potential in treating non-alcoholic fatty liver disease (NAFLD) and other inflammatory conditions due to its hepatoprotective and anti-inflammatory effects. Additionally, the compound is studied for its role in antioxidant supplements, where it helps combat oxidative stress linked to aging and chronic diseases. Its application extends to cosmetic formulations aimed at reducing skin inflammation and promoting cellular repair. The demand for rotundic acid is growing in B2B markets, particularly among manufacturers of herbal extracts and functional ingredients.
Safety and Storage
While rotundic acid is generally considered safe for use in controlled doses, proper handling is essential to avoid adverse effects. Direct contact with skin or eyes should be avoided, and protective equipment like gloves and goggles is recommended during handling. Inhalation of powder should be prevented by working in well-ventilated areas or using dust masks. Storage conditions are critical to maintaining the compound's stability. It should be kept in a cool, dry place, ideally at temperatures below 25°C, and protected from light and humidity. Bulk quantities are often packaged in aluminum foil bags or amber glass containers to minimize degradation. Always refer to the supplier's safety data sheet (SDS) for specific guidelines.
B2B Procurement Guide
When procuring rotundic acid, B2B buyers should prioritize suppliers with verified certifications, such as ISO or GMP compliance, to ensure quality and traceability. Key specifications to confirm include purity (typically ≥98% by HPLC), residual solvent levels, and heavy metal content. Requesting third-party lab reports can provide additional assurance. Bulk purchasing often offers cost advantages, but buyers should evaluate supplier reliability and batch-to-batch consistency. Lead times and shipping conditions (e.g., temperature-controlled transport) are also important considerations. For international procurement, verify compliance with regional regulations, such as the U.S. FDA or EU pharmacopeia standards, to avoid customs or legal issues.
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