Overview
Rivularin is a naturally occurring flavonoid compound primarily extracted from plants of the Rabdosia species, notably Rabdosia rubescens (Chinese name: 冬凌草). It belongs to the diterpenoid class of phytochemicals and has attracted scientific interest due to its structural uniqueness and potential bioactivities. First isolated in the 1970s, rivularin has been studied for its role in traditional medicine systems, particularly in East Asia. Modern research focuses on its possible therapeutic effects, including anti-inflammatory and antitumor properties, though clinical applications remain investigational.
Physical and Chemical Properties
Rivularin presents as a yellow crystalline solid with moderate thermal stability. Its molecular structure contains a fused ring system with hydroxyl and carbonyl functional groups, contributing to both its polarity and reactivity. The compound exhibits characteristic UV absorption maxima between 270-290 nm, useful for analytical detection. Solubility tests show preferential dissolution in organic solvents like methanol (≈30 mg/mL) and ethanol (≈20 mg/mL), with limited water solubility (<1 mg/mL). This property profile necessitates solvent selection for experimental work. The compound demonstrates stability under inert atmospheres but may degrade upon prolonged exposure to oxygen or strong light.
Main Applications
In pharmaceutical research, rivularin serves as a lead compound for developing novel therapeutic agents, particularly in oncology applications. Studies suggest it may inhibit cancer cell proliferation through multiple pathways, including NF-κB signaling modulation. However, these effects require further validation in clinical settings. The nutraceutical industry explores rivularin as a potential functional ingredient, leveraging its antioxidant capacity measured by ORAC (Oxygen Radical Absorbance Capacity) assays. Some traditional medicine preparations incorporate plant extracts containing rivularin for hepatoprotective claims, though standardized formulations are uncommon in Western markets.
Safety and Storage
As a bioactive compound, rivularin requires careful handling per laboratory safety protocols. Material Safety Data Sheets (MSDS) indicate it may cause mild irritation upon direct contact with skin or mucous membranes. Proper PPE including nitrile gloves and safety goggles is recommended during weighing and processing. Storage recommendations include amber glass containers under inert gas (argon or nitrogen) for long-term preservation. Analytical-grade material typically ships with desiccants and should be kept at -20°C if not used immediately. Stability studies indicate 2-3 year shelf life under optimal conditions when protected from humidity and oxidation.
B2B Procurement Guide
Industrial buyers should prioritize suppliers providing comprehensive analytical documentation, including HPLC purity certificates (>95% preferred), mass spectrometry confirmation, and residual solvent analysis. Batch-to-batch consistency is critical for research applications, requiring review of supplier quality control processes. Pricing varies significantly based on purity (90-99%), with small quantities (1-10g) averaging $80-150/g at 95% purity. Bulk purchases (100g+) may achieve 20-30% cost reduction. Specialized manufacturers in China and Germany currently dominate production, with lead times of 4-8 weeks for custom synthesis orders. Import/export compliance checks are advised due to varying regulations on phytochemical shipments.
Related Manufacturers
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- 主营：Rivularin、白蜡树素、百两金素、半齿泽兰素