Overview
Rifampicin is a semi-synthetic antibiotic derived from the rifamycin group, first isolated from the bacterium Amycolatopsis rifamycinica. It is classified as a first-line drug for tuberculosis (TB) and is included in the World Health Organization's List of Essential Medicines. Rifampicin is also used in combination therapies to prevent resistance development. Its discovery in the 1960s revolutionized TB treatment, significantly reducing mortality rates. Today, it remains a cornerstone of anti-TB regimens, often paired with isoniazid and pyrazinamide. Beyond TB, rifampicin is employed against leprosy and staphylococcal infections, including MRSA.
Physical and Chemical Properties
Rifampicin appears as a reddish-brown crystalline powder with limited solubility in water but dissolves well in chloroform, methanol, and dimethyl sulfoxide. Its molecular structure includes a naphthoquinone core linked to a piperazine ring, contributing to its distinctive color and stability under controlled conditions. The compound is sensitive to light and moisture, necessitating dark, airtight storage. Its melting point with decomposition (183–188°C) indicates thermal instability, requiring careful handling during formulation. Analytical techniques like HPLC and UV spectroscopy are commonly used for quality verification.
Main Applications
Rifampicin's primary application is in treating pulmonary and extrapulmonary tuberculosis, typically administered orally in 600mg daily doses. It is also a key component of the WHO-recommended Directly Observed Treatment Short-course (DOTS) strategy for TB control. In addition to TB, rifampicin is used for leprosy (as part of multidrug therapy) and prophylactic treatment of Haemophilus influenzae type b and Neisseria meningitidis infections. Off-label uses include infections involving prosthetic joints or indwelling medical devices, where biofilm penetration is critical.
Safety and Storage
Rifampicin carries a risk of hepatotoxicity, requiring liver function monitoring during therapy. Adverse effects include orange discoloration of bodily fluids, gastrointestinal distress, and potential drug interactions due to CYP450 enzyme induction. For storage, maintain original packaging in refrigerated (2–8°C), dry environments. Bulk pharmaceutical quantities should be sealed under nitrogen to prevent oxidation. Workplace handling mandates gloves, goggles, and respirators to minimize inhalation or dermal exposure risks.
B2B Procurement Guide
When procuring rifampicin for pharmaceutical manufacturing, prioritize suppliers with WHO Good Manufacturing Practice (GMP) certification. Key specifications include HPLC purity ≥98%, low heavy metal content (<10 ppm), and validated microbial limits. Consider regional regulatory requirements; for example, USP/EP standards differ in residual solvent limits. Large-volume buyers (>100kg) may negotiate 10–15% price discounts. Always audit suppliers for cold chain logistics capabilities and stability testing documentation. Spot-market purchases should include certificates of analysis with batch-specific HPLC chromatograms.
Related Manufacturers
- 主营：培养基、动物红细胞、原代细胞、细胞系、Elisa试剂盒
- 主营：抑制剂、化合物库、药物筛选、天然产物
- 主营：甲氧基聚乙二醇、氨基聚乙二醇、羧基聚乙二醇、巯基聚乙二醇、羟基聚乙二醇、马来酰亚胺聚乙二醇、四臂聚乙二醇、荧光素聚乙二醇、叠氮聚乙二醇、硅烷聚乙二醇、炔基聚乙二醇、生物素聚乙二醇、丙烯酸酯聚乙二醇、活性脂聚乙二醇、Boc保护基团聚乙二醇、Fmoc保护基团聚乙二醇、生物素小分子PEG衍生物、甲氧基小分子PEG衍生物
- 主营：木质醛、酮锌吡、褪黑素、甘油酯、粘蛋白、薄荷脑、苯氨基、苹果酸、三羟基、皮粉五、甲基蓝、生根粉、动力精、薄荷酮、二羟基、3α羟基、萘酰胺、胶粘剂、磷酸三、嗪二酮、氨酸钾、嘧啶酮、氨酸镁、407环氧、酸cas号
- 主营：桉油精、标准品、薄荷脑、中药对照品、白花前胡丙素、白藜芦醇三甲醚
- 主营：生物素修饰蛋白、fitc标记蛋白、聚苯乙烯微球、pvc微球、嵌段共聚物、生物素标记、荧光标记、纳米颗粒、核苷糖、aie、复合微球、功能化载玻片、荧光染料、金属配合物、Mxene、介孔二氧化硅微球、磁性纳米颗粒、小分子PEG、聚合物、纳米金、聚合物微球、荧光微球、荧光探针、点击化学、小分子
- 主营：D-荧光素钾、D-荧光素钠、缓冲液、裂解液、脲酶Urease、刀豆凝集素ConA、黄嘌呤氧化酶、胰α淀粉酶、β-葡萄糖苷酶、辣根过氧化物酶、植物检测试剂盒、tRNA转运核糖核酸、胰蛋白酶抑制剂、乙酰胆碱酯酶、L-乳酸脱氢酶、过氧化氢酶、葡萄糖氧化酶、肝素钠、福林酚、三羟甲基氨基甲烷、二硫苏糖醇DTT、苏木色精、伊红Y(曙红)、乙基紫、土壤检测试剂盒
- 主营：Desacetylrifampicin、莪术二酮、人参皂苷rc
- 主营：cy荧光染料、ICG吲哚菁绿、源头厂家
- 主营：草铵膦、恶霜灵、雌酚酮、溴虫腈、标准品、氟环唑、苯甲酸、大观霉素、恶唑菌酮、异丙氧磷、多拉菌素、氘代甲苯、呋喃西林、氟罗沙星、3-二氯丙烯、吡氟氯禾灵、二氯吡啶酸、二甲基吗啉、一氯二溴甲烷、硝基呋喃妥因
- 主营：正辛酸、茯苓酸、荭草素、黄连碱、桑根醇、标准品、10171-61-6、葫芦素d、菜油甾醇、枸橼苦素、藏红花酸、验用试剂、莪术烯醇、分析试剂、异紫堇定、链蠕孢素、番荔枝碱、伏立诺他、菠萝叶酯、实验试剂、科研试剂、科研用试剂、柏木双黄酮、分析对照品、甲基莲心碱
- 主营：高纯度科研试剂
- 主营：科研试剂、重组蛋白、抗体抑制剂、工具化合物
- 主营：单磷酸、白果酸、银杏酸、澳洲茄胺、红四氮唑、白当归脑、曲氟胸苷、安石榴苷、二磷酸葡、白术内酯、四氮唑蓝、澳洲茄碱、巴卡亭iii、白藜芦醇、脱氧尿苷、澳洲茄边、白当归素、脱氧腺苷、腺苷一水合、二磷酸钠盐、白花前胡丙、羟甲香豆素、尿苷三磷酸、菝葜皂苷元、磷酸二钠盐
- 主营：ringers液、聚山梨酯、葡萄糖溶液、检测试剂盒、氯化锂溶液、dna提取试剂盒、染色液、色素