Overview
Resacetophenone, chemically known as 2,4-dihydroxyacetophenone, is an organic compound with significant applications in pharmaceuticals and chemical synthesis. It is an aromatic ketone featuring hydroxyl groups at the 2 and 4 positions of the benzene ring, making it a versatile intermediate. This compound is commonly synthesized through Friedel-Crafts acylation or other organic reactions. Its structural features allow it to participate in various chemical transformations, contributing to its widespread use in research and industrial processes.
Physical and Chemical Properties
Resacetophenone appears as a pale yellow to white crystalline powder with a melting point range of 142-145 °C. It is soluble in organic solvents like ethanol, methanol, and acetone but has limited solubility in water. The presence of hydroxyl groups enhances its reactivity, enabling it to form derivatives useful in further chemical synthesis. Its stability under normal conditions makes it suitable for storage and handling in laboratory and industrial settings.
Main Applications
Resacetophenone serves as a key intermediate in the synthesis of pharmaceuticals, including active pharmaceutical ingredients (APIs) and drug precursors. Its reactivity allows for the production of various derivatives with therapeutic potential. Additionally, it is used in the manufacture of dyes and pigments, where its hydroxyl groups facilitate color formation. Its role in organic synthesis extends to agrochemicals and specialty chemicals, highlighting its versatility.
Safety and Storage
Handling resacetophenone requires standard safety precautions, including the use of gloves, goggles, and lab coats to prevent skin and eye contact. Inhalation of dust should be avoided, and adequate ventilation is recommended. Storage should be in a cool, dry place, away from direct sunlight and moisture to maintain stability. Proper labeling and segregation from incompatible substances are essential to ensure safe handling and storage.
B2B Procurement Guide
When procuring resacetophenone, buyers should prioritize suppliers with verified quality certifications, such as ISO or GMP compliance. Purity levels, typically ranging from 98% to 99.5%, should be confirmed through analytical certificates. Bulk purchases may offer cost advantages, but buyers should assess lead times and supplier reliability. Packaging options, such as drums or bags, should align with storage and handling requirements to prevent contamination or degradation.
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