Overview
Rat mucin is a high molecular weight glycoprotein extracted from rat mucous secretions, primarily found in gastrointestinal, respiratory, and reproductive tracts. It serves as a crucial component in mucosal barriers, protecting epithelial surfaces from pathogens and mechanical stress. In research contexts, rat mucin is particularly valuable for comparative studies with human mucins, offering insights into mucosal biology and disease mechanisms. The glycoprotein's structure features extensive O-glycosylation, contributing to its characteristic viscoelastic properties.
Physical and Chemical Properties
Rat mucin demonstrates unique rheological properties, transitioning between viscous solutions and elastic gels depending on concentration and environmental conditions. Its carbohydrate content (40-80% by weight) includes N-acetylgalactosamine, galactose, fucose, and sialic acid residues. The protein backbone contains tandem repeat sequences rich in serine, threonine, and proline, which serve as glycosylation sites. These structural features contribute to mucin's resistance to proteolytic degradation and its ability to form hydrated networks essential for mucosal protection.
Main Applications
In biomedical research, rat mucin serves as a model system for studying mucus barrier function in respiratory diseases (e.g., COPD, asthma), gastrointestinal disorders (e.g., IBD), and reproductive health. Its immunological properties make it valuable for investigating host-pathogen interactions. The pharmaceutical industry utilizes rat mucin in drug delivery studies, particularly for evaluating mucoadhesive formulations and nanoparticle penetration through mucus barriers. Additionally, it's used in vitro to create physiologically relevant mucus models for toxicity testing and barrier function assays.
Safety and Storage
While rat mucin itself presents low toxicity, proper handling procedures should be followed as with all biological materials. Use gloves and eye protection when handling powdered forms, which may become airborne. Solutions should be prepared in biological safety cabinets when possible. For long-term storage, aliquoting is recommended to minimize freeze-thaw cycles. Lyophilized samples maintain stability for years at -20°C, while solutions are typically stable for months at 4°C with antimicrobial additives. Always verify material safety data sheets for specific product handling instructions.
B2B Procurement Guide
When procuring rat mucin for research or industrial applications, specify required parameters including: source tissue (gastric, intestinal, tracheal), purification method (e.g., density gradient centrifugation), degree of glycosylation, and endotoxin levels. Reputable suppliers should provide detailed certificates of analysis. Consider ordering small test quantities first to verify product performance in your specific applications. For larger orders, inquire about batch-to-batch consistency measures and available stability data. Lead times may vary significantly depending on purification requirements and source availability.
Related Manufacturers
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、细胞、生物试剂、进口ELISI试剂盒、PCR试剂盒
- 主营：大鼠粘蛋白粘液素5B、elisa试剂盒
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、大鼠粘蛋白ELISA试剂盒、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒
- 主营：ELISA试剂盒、抗体
- 主营：大鼠粘蛋白、试剂盒、ELISA试剂盒、ELISA检测试剂盒
- 主营：大鼠粘蛋白、检测试剂盒
- 主营：大鼠粘蛋白、试剂盒
- 主营：scl-70igg、人1α羟、试剂盒、大鼠11β、大鼠8羟基、大鼠25羟基、葡聚糖、16α羟基、1iga抗体、胶原c端、2-he2elisa、1igm抗体、25二羟基、17羟孕酮、dna糖苷酶、5α还原酶、研启生物、去氢血栓、人胰岛素、胶原n末端、25羟基维生、2，5寡腺苷、11脱氢血栓、羟基壬烯醛、三磷酸肌醇
- 主营：粘蛋白、elisa试剂盒、试剂盒、抗体
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、大鼠粘蛋白、科研试剂
- 主营：ELISA试剂盒、高灵敏度试剂盒、试剂盒厂家、大鼠ELISA试剂盒、特种蛋白检测ELISA试剂盒、人ELISA试剂盒、小鼠ELISA试剂盒、仓鼠ELISA试剂盒、豚鼠ELISA试剂盒、鸡ELISA试剂盒、鸭ELISA试剂盒、牛ELISA试剂盒、羊ELISA试剂盒、马ELISA试剂盒、猴ELISA试剂盒、猪ELISA试剂盒、犬ELISA试剂盒、兔ELISA试剂盒、鱼ELISA试剂盒、植物ELISA试剂盒、土壤ELISA试剂盒、定性ELISA试剂盒、肿瘤标志物检测ELISA试剂盒、传染病检测ELISA试剂盒
- 主营：试剂盒、同源物、抑制素、脂蛋白、合蛋白、粘液素、蛋白酶、凝蛋白、亲环素、保护素、信号素、胞色素、脂肪酶、末端肽、磷脂酶、变位酶、抑制剂、脱水酶、抑制物、激活肽、连接酶、样激酶、解氨酶、恒温箱、利钠肽
- 主营：大鼠粘蛋白、检测试剂盒、elisa试剂盒
- 主营：脂肪酸结合蛋白、特异性抗原、带状疱疹病毒、人乙酰胆碱酯酶
- 主营：elisa试剂盒、生化试剂盒、pcr检测试剂盒、粘蛋白粘液素5B、细胞