Overview
Bombesin is a neuropeptide first identified in the skin of the European fire-bellied toad (Bombina bombina). It belongs to the gastrin-releasing peptide (GRP) family and is known for its role in stimulating gastric acid secretion and smooth muscle contraction. In mammals, bombesin-like peptides regulate various physiological functions, including appetite, thermoregulation, and stress responses. Due to its biological significance, bombesin is widely studied in medical and pharmacological research.
Physical and Chemical Properties
Bombesin is a 14-amino acid peptide with the molecular formula C71H110N24O18S. It appears as a white to off-white powder and is soluble in water and acetic acid. The peptide is stable under recommended storage conditions (-20°C in a dry, dark place). Its high biological activity makes it a valuable tool in research, particularly in studies involving gastrointestinal function and hormone secretion. The peptide's stability and solubility are critical for experimental applications.
Main Applications
Bombesin is primarily used in medical research to study gastrointestinal physiology, hormone regulation, and cancer cell proliferation. It has been investigated for its potential role in diagnosing and treating certain cancers, such as small cell lung cancer. Additionally, bombesin is utilized in neuroscience research to explore its effects on appetite and stress responses. Its ability to bind to specific receptors (BB1, BB2) makes it a valuable probe for studying receptor-ligand interactions.
Safety and Storage
Bombesin should be handled with care, using appropriate protective equipment to avoid inhalation or direct contact. Proper storage at -20°C in a dry, dark place is essential to maintain its stability and activity. Researchers should follow laboratory safety protocols, including the use of gloves and eye protection. Disposal should comply with local regulations for biological and chemical waste.
B2B Procurement Guide
When procuring bombesin, verify the supplier's credibility and the product's purity, typically assessed via HPLC. Ensure the peptide is shipped under controlled conditions to prevent degradation. Prices vary based on purity and quantity, with research-grade bombesin costing approximately $100-$500 per mg. Consider bulk purchasing for cost savings, but prioritize quality and storage conditions to maintain efficacy.
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