Overview
(R)-Ethanol is the dextrorotatory enantiomer of ethanol, distinguished by its ability to rotate plane-polarized light to the right. While standard ethanol is a racemic mixture, (R)-ethanol is specifically used in applications requiring chiral specificity. It is primarily utilized in pharmaceutical manufacturing, where enantiomeric purity is critical for drug efficacy and safety. Additionally, it serves as a reagent in asymmetric synthesis and fine chemical production.
Physical and Chemical Properties
(R)-Ethanol shares most physical properties with racemic ethanol, including boiling point, density, and solubility. Its key distinction lies in its optical activity, with a specific rotation of approximately +15.8° at 20°C (sodium D-line). The compound is highly flammable (flash point: 13°C) and forms explosive vapor-air mixtures. It reacts vigorously with oxidizing agents and certain metals like alkali metals and aluminum hydride.
Main Applications
In the pharmaceutical industry, (R)-ethanol is valued as a chiral auxiliary in drug synthesis, particularly for producing single-enantiomer medications where the R-configuration is biologically active. It also finds use in specialty chemical manufacturing, particularly for producing chiral catalysts and resolving agents. Research laboratories employ it for studying stereospecific reactions and enzyme-substrate interactions.
Safety and Storage
As a flammable liquid, (R)-ethanol requires storage in approved safety containers away from heat and ignition sources. Proper grounding is essential during transfer to prevent static discharge. Personal protective equipment including chemical goggles and flame-resistant clothing should be used when handling. Spills should be absorbed with inert material and disposed of properly, as the compound is toxic to aquatic life.
B2B Procurement Guide
When sourcing (R)-ethanol commercially, prioritize suppliers who provide detailed certificates of analysis including enantiomeric excess (typically ≥98%). Pharmaceutical-grade material should have appropriate GMP documentation. Bulk purchases (drum quantities or larger) typically offer better pricing, but verify storage capabilities before ordering. Consider regional suppliers to minimize shipping hazards for this flammable material.
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