Overview
Quinic acid is a naturally occurring organic compound classified as a cyclitol, commonly found in plants such as coffee beans, cinchona bark, and some fruits. It plays a crucial role in the shikimate pathway, which is vital for the biosynthesis of aromatic amino acids in plants. Industrially, quinic acid is valued for its applications in pharmaceuticals, where it serves as an intermediate in drug synthesis, and in the food industry as a flavoring agent and preservative. The compound is known for its chiral properties, making it useful in stereospecific synthesis. Its non-toxic nature and stability under normal conditions further enhance its versatility in various industrial applications.
Physical and Chemical Properties
Quinic acid appears as a white crystalline powder with a molecular weight of 192.17 g/mol. It has a density of 1.64 g/cm³ and a melting point of 160-162°C, where it begins to decompose. The compound is highly soluble in water and slightly soluble in ethanol, making it suitable for aqueous solutions in industrial processes. Chemically, quinic acid is a cyclic polyol with four hydroxyl groups and one carboxyl group. Its chiral centers allow it to exist in various stereoisomeric forms, which can be exploited in asymmetric synthesis. The compound is stable under normal storage conditions but should be protected from prolonged exposure to light and moisture to prevent degradation.
Main Applications
Quinic acid is widely used in the pharmaceutical industry as an intermediate in the synthesis of antiviral and antibacterial drugs. Its role in the shikimate pathway makes it a valuable precursor for aromatic compounds. Additionally, it is used in the production of chiral catalysts and ligands for asymmetric synthesis. In the food industry, quinic acid serves as a natural flavoring agent, particularly in coffee-based products, where it contributes to the characteristic tartness. It is also employed as a preservative due to its mild antimicrobial properties. Beyond these applications, quinic acid is explored in cosmetic formulations for its potential skin-beneficial effects.
Safety and Storage
Quinic acid is generally regarded as safe (GRAS) for use in food and pharmaceuticals, with low toxicity. However, standard laboratory precautions should be followed, including avoiding inhalation of dust and direct contact with eyes. In case of contact, rinse thoroughly with water. For storage, quinic acid should be kept in a cool, dry place, away from light and moisture to maintain its stability. Properly sealed containers are recommended to prevent contamination and degradation. Bulk quantities should be stored in a well-ventilated area to avoid dust accumulation.
B2B Procurement Guide
When procuring quinic acid for industrial use, it is essential to verify the CAS number (77-95-2) to ensure the correct compound. Purity levels should be confirmed, especially for pharmaceutical applications, where high-grade (≥98%) material is typically required. Suppliers should provide certificates of analysis (CoA) and relevant safety data sheets (SDS). Price ranges vary based on purity and order volume, with common market prices between $50 and $150 per kilogram. Buyers should consider sourcing from reputable manufacturers with ISO or GMP certifications to guarantee quality and consistency. Additionally, inquire about packaging options, such as drums or bags, to suit specific handling and storage needs.
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