Overview
Pyrazine is a heterocyclic aromatic compound with the molecular formula C4H4N2. It consists of a six-membered ring containing four carbon atoms and two nitrogen atoms at opposite positions. Pyrazine and its derivatives are widely used in various industries, including pharmaceuticals, agrochemicals, and food flavoring. Pyrazine derivatives are particularly significant in medicinal chemistry due to their bioactive properties. They are found in many drugs, including antituberculosis and antihypertensive medications. Additionally, pyrazine is used as a building block in the synthesis of more complex organic compounds.
Physical and Chemical Properties
Pyrazine is a colorless to pale yellow crystalline solid with a distinctive nutty odor. It has a melting point of 52-54 °C and a boiling point of 115-116 °C. The compound is soluble in water and common organic solvents such as ethanol, ether, and benzene. Pyrazine is an aromatic compound, meaning it exhibits resonance stabilization. The presence of two nitrogen atoms in the ring enhances its ability to participate in hydrogen bonding and other intermolecular interactions. These properties make pyrazine a versatile intermediate in organic synthesis.
Main Applications
Pyrazine is primarily used in the pharmaceutical industry as a precursor for various drugs, including antituberculosis agents like pyrazinamide. It is also employed in agrochemicals, where it serves as a building block for herbicides and pesticides. In the food industry, pyrazine derivatives are valued for their flavoring properties. They contribute to the taste and aroma of roasted foods, coffee, and chocolate. Additionally, pyrazine is used in fragrances and as a ligand in coordination chemistry.
Safety and Storage
Pyrazine should be handled with care to avoid exposure. It may cause irritation to the skin, eyes, and respiratory system. Proper personal protective equipment, including gloves and goggles, should be worn when handling the compound. Store pyrazine in a cool, dry, well-ventilated area away from heat sources and open flames. Ensure containers are tightly sealed to prevent contamination and moisture absorption. In case of spills, use appropriate absorbent materials and dispose of them according to local regulations.
B2B Procurement Guide
When procuring pyrazine, verify the CAS number (290-37-9) and purity specifications to ensure product quality. Reputable suppliers should provide certificates of analysis (CoA) and comply with international standards such as USP or EP. Consider the intended application when selecting a grade of pyrazine. Pharmaceutical-grade pyrazine is required for drug synthesis, while industrial-grade may suffice for flavoring or agrochemical uses. Bulk purchases may offer cost savings, but ensure proper storage conditions to maintain product integrity.
Related Manufacturers
- 主营：6-二羟基吲哚、磷钼酸、艾拉莫德中间体、2-辛基十二醇、甲基丙二酸、光引发剂、苯芴醇、溴芬酸钠中间体、樟脑醌、钼酸钾、丝素蛋白、盐酸胍、β-丙氨酸甲酯盐酸盐、聚二羟基吲哚、7-去氢胆固醇、甘氨胆酸钠盐、半叶素、胆固醇、蛋白酶K、D-荧光素钾盐、光引发剂LAP、BIS-TRIS、甲基丙烯酸氧杂环丁烷
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：油漆涂料、涂料溶剂
- 主营：乙二醇、二甲基亚砜、丙二醇、吡嗪、精对苯二甲酸、己二酸、聚乙烯醇、聚乙二醇、木质素、甘油、三甘醇、己内酰胺、叔十二硫醇、白油、对苯二甲酸二甲酯、4-丁二醇
- 主营：二甲基亚砜、乙二醇、丙二醇、23、DMAC
- 主营：6-二羟基吲哚、二羟基吲哚啉氢溴酸、水解角蛋白、2-辛基十二醇、2-巯基噻唑啉、2-巯基苯并咪唑、7-去氢胆固醇、石胆酸钠盐、熊去氧胆酸钠盐、苯基周位酸(8-苯胺、L-丙交酯、半叶素、乙烯利、环丙磺酰胺、苄氧基胺盐酸盐、1-氨基环丙烷羧酸、4-联苯甲醇丙烯酸酯、4-羟乙烯基氧基二苯、咪鲜胺、可比落、乙交酯、D(+)-丙交酯
- 主营：丙二胺、十四酸、棕榈酸、氰基吡嗪、正壬胺、十烷酸、苯酰氯、醋酰胺、甲酸钠、工业级1、工业级e0、工业级mpd、十二叔胺、四氢呋喃、四甲撑硫、cyc环己酮、聚合醇胺、六氢苯酐、月桂酰胺、丙烯酰氯、十六叔胺、氯乙酰氯、盐酸羟胺、苯磺酰氯、蓖麻油酸、苯扎氯铵
- 主营：乙酰基吡嗪、硫化锰、丙酮缩甘油、甲基三丁基膦磷酸二甲酯盐
- 主营：氯化钠、除味剂、聚乙烯胺、2-丁二醇、二羟醋酸、肌氨基酸、聚乙烯铵、米诺地尔、醋酸亚铁、一水肌酸、树苔浸膏、纳米勃姆石、花椒油树脂、醋酸氯己定、糊状叶绿素、无味子醇甲、三硬脂酸铝、聚乙烯亚胺、胡椒基丁醚、全氟三丁胺、5-甲氧基色胺、聚酰亚胺树脂、人造康酿克油、有机硅季铵盐、氯化十六吡啶
- 主营：乙醛酸、铁甲酸、二甲基、2-羟基喹喔啉、2-苯并唑啉酮、2-氨基-5-氯苯酚、羟乙基、草酰胺、3-氯丙炔、邻苯二甲、苯甲酰胺、溴氯海因、3-氯水扬酸、磷酸三甲酯、对羟基苯海因、3-环戊二羧酸、6-二氯异烟酸
- 主营：氨基酸、辅酶试剂、通用溶剂、常用耗材、有机砌块、基础溶剂、科研耗材、化工试剂、超干溶剂、氘代试剂、试剂耗材、生物试剂、实验室耗材、分析对照品、管通透析装、线限佐菌素、助力实验室、牛磺去氧胆酸、核酸相关试剂、蛋白相关试剂、辅酶核心试剂、蛋白相关耗材、相关化学试剂、科研常用试剂、薄层层析硅胶板
- 主营：1783-96-6、9003-11-6、谷氨酸、6920-22-5、3493-12-7、3697-42-5、9012-76-4、3934-20-1、2687-91-4、1119-34-2、2744-50-5、2971-90-6、7462-74-0、6020-87-7、5466-06-8、柠檬酸、4767-03-7、4559-86-8、7601-54-9、精氨酸、4337-33-1、碘化锂、dl-泛醇、1984-06-1、6440-58-0
- 主营：尼龙66盐、聚乙二醇、涂料树脂、氰基吡嗪、表面活性剂、二甲基甲酰胺、英威达己二胺、nn二甲基乙醇胺
- 主营：甲基吡嗪、氨基丁酸、胍基乙酸
- 主营：苄基丙酮