Overview
Propargyl Polyethylene Glycol Amine is a bifunctional linker molecule combining an alkyne group (for copper-catalyzed azide-alkyne cycloaddition) with a reactive amine through a polyethylene glycol (PEG) spacer. This unique structure makes it invaluable in bioconjugation and materials science. The compound's modular design allows customization of PEG chain length (typically 3-24 ethylene oxide units) to balance hydrophilicity and steric effects. Its commercial availability in various molecular weights has expanded applications in pharmaceutical research and advanced material development.
Physical and Chemical Properties
The compound exhibits typical PEG characteristics - high water solubility, low toxicity, and resistance to protein adsorption. The terminal propargyl group enables click chemistry reactions at room temperature with azide-functionalized molecules. Key reactivity includes: 1) Amine group participation in NHS ester or isocyanate couplings 2) Alkyne group's cycloaddition with azides 3) PEG spacer's resistance to nonspecific binding. The viscosity increases significantly with longer PEG chains, affecting handling procedures in industrial applications.
Main Applications
In biopharmaceuticals, it serves as a linker for antibody-drug conjugates (ADCs) and PEGylation of therapeutic proteins. The PEG spacer improves solubility and reduces immunogenicity of conjugated drugs. Material scientists utilize it for surface functionalization of nanoparticles and hydrogels. Its dual functionality allows sequential conjugation strategies - first anchoring via amine groups, then click chemistry modifications. Recent advances include biosensor development and 3D bioprinting applications where controlled crosslinking is essential.
Safety and Storage
As a moisture-sensitive compound, it requires storage under argon or nitrogen at -20°C. Desiccants should accompany shipments, and containers must be tightly sealed after each use. Safety protocols mandate nitrile gloves, eye protection, and fume hood use. While not highly toxic, the amine group can cause irritation. Spills should be absorbed with inert material and disposed as chemical waste. Never mix with strong oxidizers due to the alkyne group's reactivity.
B2B Procurement Guide
Industrial buyers should specify: 1) Exact PEG chain length (monodisperse or polydisperse) 2) Degree of end-group functionalization (>95% preferred) 3) Absence of diol impurities 4) Certificate of Analysis including NMR and HPLC data. Bulk quantities (100g+) often require 4-8 weeks lead time. Consider suppliers offering custom PEG lengths and dual-bottle packaging (amine protected as HCl salt, alkyne group free). For GMP applications, request DMF references and residual solvent testing.
Related Manufacturers
- 主营：乙醇胺、mpeg-maca、甲醚酰肼、单甲醚氨基、单甲醚丙炔、聚乙二醇单甲醚、单甲醚乙酸、马来酰亚胺、单甲醚马来、单甲醚叠氮、单甲醚卤代烃、单甲醚苯甲醛、甲醚环氧丙烷、甲基丙烯酸酯、甲醚二苯基环、甲醚异氰酸酯、单甲醚乙烯基
- 主营：催化剂、peg试剂、cy5四氮、氨基聚乙二醇丙炔、活性脂、苯二胺、2406-34-0、乙氧基、试剂cas、环辛烯、生物素、cb-cyclam、实验室、dbco-acid、半乳糖、溴苯基、交联剂、环己炔、荧光素、3694-51-7、ac4galnal、2001-96-9、葡萄糖、环辛炔、直发cas、糖化学
- 主营：反应活、hydrazide、修饰剂、丙炔一聚乙二醇、催化剂、糖蛋白、连接子、激动剂、聚合物、活性脂、胆固醇、钆特酸、催化性、dna标记、络合剂、荧光试剂、雨蛙素、乙二胺、ped结构、衍生物、化合物、链接剂、反应物、生物素
- 主营：聚乙二醇、单分散peg、马来酰亚胺
- 主营：在水中、包含肽、含叠氮、丙炔基、由氨基、氨基nh2、菁染料、peg单元、具有炔、胺hcl盐、阿尔法、催化剂、peg试剂、结构式、3694-51-7、碘化物、4727-50-8、具有两、带有炔、磺酸基、3065-79-0、aminopeg8、甲基九、bcn基团、荧光素
- 主营：2d碳化钒、单层mbene、陶瓷材料、聚乙二醇、mab相材料、mbene前驱体、ti3c2tx柔性膜、免疫因子纳米载体服务
- 主营：活性脂、三苯胺、mof材料、聚乙二醇、海藻酸钠、聚苯乙烯、蛋白交联剂、琥珀酰亚胺酯、月桂酸甘油酯、二元醛基cof单体
- 主营：上转换纳米粒子、嵌段聚合物、纳米材料、聚乙二醇PEG衍生物、荧光染料、金纳米粒、银纳米粒、二氧化硅、聚苯乙烯、四氧化三铁