Overview
Prilocaine is a local anesthetic belonging to the amino amide group, first introduced in the 1960s. It is widely used in medical and dental procedures due to its rapid onset and moderate duration of action. Unlike some other anesthetics, prilocaine has a lower risk of causing allergic reactions, making it suitable for patients with sensitivities. Prilocaine is often combined with other anesthetics like lidocaine in formulations such as EMLA cream, which is used for topical anesthesia. Its efficacy and safety profile have made it a staple in both clinical and outpatient settings.
Physical and Chemical Properties
Prilocaine is a white to off-white crystalline powder with a molecular weight of 220.31 g/mol. It has a melting point of 37-39°C and is soluble in water, ethanol, and chloroform. These properties make it versatile for various pharmaceutical formulations. The compound's stability under normal storage conditions ensures a long shelf life when kept in a cool, dry place. Its solubility profile allows for easy incorporation into injectable solutions and topical preparations, enhancing its utility in medical applications.
Main Applications
Prilocaine is primarily used as a local anesthetic in medical and dental procedures. It is effective for minor surgical interventions, dental work, and dermatological treatments. Its rapid onset of action makes it ideal for procedures requiring quick anesthesia. In combination with lidocaine, prilocaine is used in EMLA cream, a topical anesthetic for skin procedures like venipuncture and laser treatments. This combination reduces pain and discomfort, improving patient experience during minor invasive procedures.
Safety and Storage
Prilocaine is generally safe when used as directed, but high doses can cause methemoglobinemia, a condition that reduces oxygen delivery in the blood. Patients with cardiovascular conditions or those taking certain medications should use prilocaine with caution. Proper storage is essential to maintain prilocaine's efficacy. It should be kept in a cool, dry place, protected from light and moisture. Pharmaceutical-grade prilocaine must comply with stringent purity standards to ensure safety and effectiveness.
B2B Procurement Guide
When procuring prilocaine for B2B purposes, verify the supplier's compliance with pharmaceutical standards such as Good Manufacturing Practices (GMP). Ensure the product's CAS number (721-50-6) matches to avoid counterfeit materials. Purity and quality certifications are critical for pharmaceutical applications. The reference price for prilocaine ranges from approximately $50 to $100 per gram, depending on purity and quantity. Bulk purchases may offer cost savings, but quality should never be compromised.