Overview
Populin is a phenolic glycoside derived from the bark and leaves of poplar trees (Populus species), particularly Populus nigra and Populus tremula. It is structurally related to salicin, a well-known precursor to aspirin, but features an additional benzoyl group attached to the glucose moiety. This modification enhances its bioactivity and solubility, making it a compound of interest in both traditional and modern medicine. Historically, poplar bark extracts containing populin have been used in folk medicine for their anti-inflammatory and pain-relieving effects. Today, populin is studied for its potential therapeutic applications, including its role in modulating inflammatory pathways and its use as a natural analgesic.
Physical and Chemical Properties
Populin appears as a white to off-white crystalline powder with a melting point of approximately 185-187°C. It is soluble in polar organic solvents like ethanol and methanol, as well as hot water, but exhibits limited solubility in cold water. The compound's molecular weight is 390.38 g/mol, and its structure includes a glucose unit bonded to a salicyl alcohol moiety and a benzoyl group. Key chemical properties include its stability under normal storage conditions, though it should be protected from prolonged exposure to light and moisture to prevent degradation. Populin's glycosidic bond makes it susceptible to enzymatic hydrolysis, which can release salicin and benzoic acid derivatives in biological systems.
Main Applications
Populin is primarily used in the pharmaceutical and herbal medicine industries. Its anti-inflammatory and analgesic properties make it a candidate for inclusion in natural pain-relief formulations, often as an alternative or adjunct to synthetic drugs. Research has explored its potential in treating conditions like arthritis and minor inflammatory disorders. In addition to therapeutic applications, populin serves as a reference standard in analytical chemistry for quality control of poplar-derived extracts. It is also studied in phytochemistry and pharmacology for its bioactive effects and mechanism of action. Some cosmetic formulations incorporate populin for its purported skin-soothing properties.
Safety and Storage
Populin is generally considered safe when handled properly, but precautions are necessary to avoid adverse effects. Direct contact with skin or eyes should be avoided, and PPE (gloves, goggles) is recommended during handling. Inhalation of dust particles should be prevented by working in a well-ventilated area or using a fume hood. Storage conditions are critical to maintaining populin's stability. It should be kept in a tightly sealed container in a cool, dry place, away from direct sunlight and moisture. Long-term storage may require refrigeration or desiccants to preserve purity. Disposal should follow local regulations for organic compounds.
B2B Procurement Guide
When sourcing populin for commercial or research purposes, buyers should prioritize suppliers with verifiable certifications, such as ISO 9001 or GMP compliance, to ensure quality and traceability. Key specifications to confirm include purity (typically ≥98% for pharmaceutical applications), residual solvent levels, and microbiological contamination limits. Pricing varies based on quantity, purity, and supplier reputation. Bulk purchases (e.g., 100 grams or more) often qualify for discounts. Buyers should request certificates of analysis (CoA) and consider third-party testing for critical applications. Lead times can range from 2-6 weeks, depending on supplier stock and customization requirements.
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