Overview
Poly(lactic-co-caprolactone) (PLCL) is a synthetic aliphatic polyester copolymer combining lactic acid and ε-caprolactone monomers. Developed as an improvement over pure PLA, it offers enhanced flexibility and degradation rate control through adjustable monomer ratios. The material gained prominence in the 2000s for medical applications due to its FDA approval and tunable mechanical properties. Its composition typically ranges from 70:30 to 50:50 lactic acid to caprolactone, allowing manufacturers to balance strength and elasticity for specific applications.
Physical and Chemical Properties
PLCL exhibits intermediate properties between its parent polymers. The caprolactone segments provide elasticity (up to 500% elongation at break), while lactic acid contributes to tensile strength (10-50 MPa). The glass transition temperature ranges from -10°C to 40°C depending on composition. Degradation occurs via hydrolysis of ester bonds, with rates adjustable from months to years. In vitro studies show complete degradation into non-toxic metabolites. The material demonstrates excellent oxygen barrier properties (5-10 cc·mil/100 in²/day), making it suitable for food packaging applications.
Main Applications
In biomedicine, PLCL dominates absorbable surgical sutures and mesh implants due to its predictable degradation profile. The FDA-approved material accounts for 35% of the bioresorbable stent market. Drug-eluting PLCL microspheres enable controlled release of therapeutics over weeks to months. Industrial applications include compostable food packaging films and agricultural mulch. Recent developments include 3D-printed PLCL scaffolds for tissue engineering, leveraging its shape-memory properties at body temperature. The textile industry utilizes PLCL fibers for biodegradable protective gear.
Safety and Storage
While PLCL is generally regarded as safe, processing requires precautions. Thermal degradation above 200°C may release caprolactone vapors, necessitating local exhaust ventilation. Powder forms may cause respiratory irritation—use NIOSH-approved particulate respirators during handling. Storage should maintain relative humidity below 30% to prevent premature hydrolysis. Double-layer aluminum foil bags with desiccants are recommended for long-term storage. Sterile medical-grade PLCL requires gamma radiation shielding and typically has a 24-month shelf life when stored at 4-8°C.
B2B Procurement Guide
Medical-grade PLCL requires ISO 13485 certification and USP Class VI biocompatibility documentation. Key specifications to request include: monomer ratio (e.g., 70:30 LA:CL), inherent viscosity (0.5-3.0 dl/g), and residual monomer content (<1%). Industrial buyers should verify compostability certifications (EN 13432, ASTM D6400) for packaging applications. Bulk orders (500kg+) typically secure 10-15% price reductions. Consider suppliers with in-house polymerization capabilities for custom formulations, with lead times of 6-8 weeks for specialty grades.
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