Overview
Phosphorylcholine (PC) is a quaternary ammonium compound and a derivative of choline. It is a key component of phospholipids, which are essential for cell membrane structure and function. PC is widely studied in biochemistry and medical research due to its role in cellular signaling and its biocompatibility. In industrial and medical applications, phosphorylcholine is used to create biocompatible coatings for medical devices, such as stents and catheters. Its ability to resist protein adsorption makes it valuable for reducing immune responses in implants.
Physical and Chemical Properties
Phosphorylcholine is a white crystalline powder with high solubility in water and polar solvents. Its molecular structure includes a positively charged quaternary ammonium group and a negatively charged phosphate group, making it zwitterionic at physiological pH. The compound is stable under normal storage conditions but may decompose at temperatures above 200°C. Its hydrophilic nature makes it useful in aqueous solutions, and it is often used in buffer systems for biochemical assays.
Main Applications
Phosphorylcholine is primarily used in biochemistry and medical applications. It is a critical component of phosphatidylcholine, a major phospholipid in cell membranes. Researchers use PC to study membrane dynamics and lipid-protein interactions. In the medical field, phosphorylcholine-based coatings are applied to implants to reduce thrombogenicity and improve biocompatibility. These coatings are particularly common in cardiovascular devices, such as stents and catheters, where they help prevent adverse immune reactions.
Safety and Storage
Phosphorylcholine is generally considered non-toxic, but standard laboratory safety precautions should be followed. Avoid inhalation of dust and direct contact with eyes or skin. In case of exposure, rinse thoroughly with water. Store phosphorylcholine in a cool, dry place, away from moisture and direct sunlight. Sealed containers are recommended to prevent degradation. For long-term storage, consider keeping the compound in a desiccator or under inert gas to maintain stability.
B2B Procurement Guide
When procuring phosphorylcholine for industrial or research purposes, verify the purity level required for your application. High-purity grades (≥98%) are typically needed for medical and biochemical uses. Supplier reliability is critical; look for certifications such as ISO or GMP compliance. Bulk purchases may offer cost savings, but ensure proper storage conditions are maintained during transit. Request material safety data sheets (MSDS) and certificates of analysis (CoA) to confirm product specifications.
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