Overview
Phloroglucinol, chemically known as 1,3,5-trihydroxybenzene, is an organic compound with significant applications in pharmaceuticals and industrial chemistry. It is a white to yellowish crystalline powder with antiseptic and antispasmodic properties, making it a key ingredient in medical formulations. The compound is also used as a reducing agent and in the synthesis of dyes and other organic compounds. First isolated in the 19th century, phloroglucinol has since become a staple in various chemical processes. Its versatility and relatively simple synthesis have contributed to its widespread use in both laboratory and industrial settings.
Physical and Chemical Properties
Phloroglucinol is characterized by its high solubility in water and organic solvents like ethanol and ether. It has a melting point of 218-220°C and a density of 1.46 g/cm³. The compound is stable under normal conditions but should be protected from light and moisture to prevent degradation. As a triol, phloroglucinol exhibits strong reducing properties and can form complexes with various metals. Its aromatic structure allows it to participate in numerous chemical reactions, including electrophilic substitution and condensation, making it valuable in synthetic chemistry.
Main Applications
In the pharmaceutical industry, phloroglucinol is used as an antispasmodic agent, particularly in treatments for gastrointestinal disorders. Its antiseptic properties also make it useful in topical medications. Additionally, the compound serves as a precursor in the synthesis of dyes, resins, and other organic materials. In analytical chemistry, phloroglucinol is employed as a reagent for detecting lignin and other phenolic compounds. Its ability to form colored complexes with certain metals enhances its utility in qualitative and quantitative analyses.
Safety and Storage
Phloroglucinol should be handled with care to avoid inhalation or skin contact, which can cause irritation. Proper protective equipment, including gloves and goggles, is recommended when working with this compound. Storage conditions should be cool, dry, and away from direct light to maintain stability. The compound is not highly toxic but should be disposed of in accordance with local regulations to minimize environmental impact. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety guidelines.
B2B Procurement Guide
When procuring phloroglucinol, it is essential to verify the CAS number (108-73-6) to ensure product authenticity. Suppliers should provide certificates of analysis (CoA) detailing purity levels, which typically range from 98% to 99.9%. Pricing varies based on quantity and purity, with bulk purchases often attracting discounts. Reliable suppliers are critical, especially for pharmaceutical-grade phloroglucinol. Buyers should assess supplier reputation, delivery timelines, and compliance with international standards such as ISO or GMP. Sample testing before large-scale procurement is advisable to confirm quality.
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