Overview
Phlorizin is a bioactive compound naturally occurring in apple trees (Malus domestica), particularly concentrated in the root bark. As a dihydrochalcone glucoside, it has attracted scientific interest for its unique ability to inhibit sodium-glucose transport proteins (SGLTs), which are critical in intestinal glucose absorption and renal glucose reabsorption. First isolated in 1835, phlorizin serves as a model compound for developing SGLT2 inhibitor drugs like canagliflozin. Beyond pharmaceuticals, it is studied for its antioxidant properties and potential applications in functional foods and agricultural sciences.
Physical and Chemical Properties
Phlorizin crystallizes as a white powder with moderate solubility in polar organic solvents but limited water solubility. Its molecular structure consists of a phloretin aglycone bound to a glucose moiety, which is essential for its biological activity. The compound exhibits stability under dry, dark conditions but may degrade upon prolonged exposure to UV light or high humidity. Analytical methods such as HPLC-UV are commonly employed to assess its purity, which typically exceeds 98% in commercial grades for research purposes.
Main Applications
In biomedical research, phlorizin is primarily used to study glucose metabolism due to its competitive inhibition of SGLT1/2 transporters. This mechanism underpins its role in preclinical diabetes studies and drug development. Nutraceutical formulations increasingly incorporate phlorizin for its potential metabolic benefits, though human clinical data remains limited. In agriculture, it functions as a natural defense compound in apple trees against pathogens, prompting investigations into its use as a biopesticide.
Safety and Storage
While phlorizin is generally low in toxicity, laboratory handling requires standard precautions including gloves and eye protection. Inhalation of dust should be avoided, and adequate ventilation is recommended during weighing procedures. Long-term storage stability is achieved at temperatures below 25°C with desiccants. Suppliers typically package the compound in amber glass vials or foil-lined bags to minimize photodegradation, with a recommended shelf life of 2-3 years when properly stored.
B2B Procurement Guide
Bulk purchasers should prioritize suppliers that provide comprehensive analytical documentation, including HPLC chromatograms and mass spectrometry verification. Current market pricing varies significantly based on purity (research-grade 95%-99.5%) and order volume. For pharmaceutical applications, regulatory filings may require additional documentation such as residual solvent reports and heavy metal analysis. Just-in-time procurement is advisable due to the compound's sensitivity to environmental conditions during transit.
Related Manufacturers
- 主营：苦参碱母液、黑米花青素、白芍提取物芍药苷、根皮甙98、苦参提取物、枸杞提取物、侧柏叶提取物
- 主营：苦参碱、氧化苦参碱、七叶皂苷钠、根皮甙、七叶皂苷、黑米花色苷、鬼臼树脂、鬼臼毒素、黑米花青素、龙胆苦苷、青蒿琥酯、青蒿素、吴茱萸碱、吴茱萸次碱、博落回总碱、鱼藤酮、二苯乙烯苷、丝肽粉、人参皂甙
- 主营：提取物、浓缩粉、生粉、苹果根皮甙、果粉、六盘韵生物
- 主营：党参提取物、苦瓜粉、甘草提取物、苹果多酚批发价格、黄芪提取物、枸杞提取物、葛根提取物、黄精提取物、山药粉、山楂提取物、鸡内金提取物、酸枣仁提取物、火麻仁提取物、桔梗提取物、茯苓提取物
- 主营：桑叶多糖、阿萨伊果粉、刺梨提取物、苹果皮黄酮、葡萄籽提取物、花青素、虾青素、龙眼肉多糖、蚌肉多糖、淫羊藿甙、茶皂素、纳豆激酶、黄连提取物、熊果苷、罗汉果甜甙、芍药苷、桔梗提取物、白毛银露梅提取物
- 主营：人参皂苷、三七皂苷、西洋参皂苷、根皮甙、番泻叶提取物、芍药苷、橄榄苦苷、茶皂素、补骨脂酚、白桦茸黑金颗粒、淫羊藿提取物、蓝莓花青素
- 主营：果粉、浸膏、生粉、苹果皮提取物、蛋白粉
- 主营：清蛋白、贝壳粉、甘草粉、根皮甙、山药粉、生物素、花青素、罗勒籽、提取液、海参粉、羊桃粉、苦瓜茶、肉桃粉、生姜片、干姜片、干冻粉、粉200目、腊肠果、藏雪莲、中药材、生梅粉、物纯粉、提取粉、猴头菇、蓝莓粉、鹅不食
- 主营：药食同源、新资源食品、果蔬粉、根皮甙、小分子肽、含量产品、动物保健常用原料、化妆品常用原料
- 主营：枸杞提取物、甘草提取物、金银花提取物、苹果根提取物市场、荷叶提取物、茯苓提取物、百合提取物、芦荟提取物、沙棘果粉、沙棘黄酮、黄芪提取物、白桦茸提取物、肉苁蓉提取物、白芍提取物、葛根提取物、藜麦肽、牦牛骨髓肽、鱼胶原蛋白肽、牡蛎肽
- 主营：甘草粉、雪莲粉、陈皮粉、苹果粉、桑葚粉、沙棘果粉、黄芩粉、草莓粉、茵陈粉、茯苓粉、阿胶粉、西洋参、板蓝根粉、速溶粉、党参粉、半夏粉、杨梅粉、淫羊藿粉、葡萄籽粉、人参粉、瓜蒌子粉、肉苁蓉粉、余甘子粉、茉莉花粉、锁阳粉、红参粉
- 主营：锁阳提取物、荷叶提取物、黄芩提取物、苹果皮提取物、黄芪提取物、红参提取物、枸杞提取物、蒲公英提取物、马齿苋提取物、鱼腥草提取物、皂角提取物、透骨草提取物、菊花提取物、黄柏提取物、饲料添加剂、食品添加剂、植物提取物、黄连提取物、固体饮料、果汁粉粉、栀子苷10%~30%
- 主营：植物提取物、化妆品原料、保健品原料、苹果多酚、功能性食品原料、花青素系列产品
- 主营：精氨酸、1kg起订、氨基酸、苹果提取物、藻油ara、氨酸钾、富铬有机、夏州生物、富铬酵母、金属硫蛋白、氨基异己酸、食品级食品、营养补充剂、植物提取物、营养强化剂、大豆提取物、磷脂酰胆碱、食品强化剂、大豆异黄酮、白色结晶粉末
- 主营：植物提取物、生物多糖、化妆品原料、保健品/食品原料、中药材生粉、果蔬粉、植物花青素、日化原料、牡蛎多糖、除虫菊提取物、无患子皂苷、茶叶茶氨酸、酵母葡聚糖、生物多肽、植物萃取原料、中药材粉、蛇床子素、蛇床子提取物、天然大蒜素、百部提取物、冻干果粉、新资源食品、微囊粉、牛鞭肽、牛脾肽