Overview
Phenylbutazone Malate is a malate salt derivative of phenylbutazone, a well-known NSAID. It is primarily used in veterinary medicine due to its enhanced solubility and bioavailability compared to the parent compound. The drug is effective in managing pain and inflammation in large animals such as horses and cattle. Its development aimed to improve the pharmacokinetic properties of phenylbutazone, making it more suitable for oral or injectable administration. The malate salt form ensures better absorption and faster onset of action, which is critical in veterinary applications where rapid relief is often necessary.
Physical and Chemical Properties
Phenylbutazone Malate appears as a white to off-white crystalline powder. It is soluble in water and alcohol, which facilitates its formulation into various dosage forms. The molecular weight is approximately 422.42 g/mol, and its chemical structure combines phenylbutazone with malic acid. The compound's solubility is a key advantage, as it allows for easier preparation of solutions for injection or oral administration. Its stability under recommended storage conditions ensures long-term efficacy, provided it is kept in a cool, dry environment away from light and moisture.
Main Applications
The primary use of Phenylbutazone Malate is in veterinary medicine, particularly for treating musculoskeletal pain and inflammation in large animals. It is commonly administered to horses suffering from conditions like arthritis, laminitis, or post-surgical pain. In addition to its analgesic and anti-inflammatory effects, the drug is sometimes used off-label for other animals, though veterinary guidance is essential. Its rapid action and improved bioavailability make it a preferred choice for veterinarians needing quick and effective pain management solutions.
Safety and Storage
Phenylbutazone Malate should be handled with care to avoid inhalation or direct skin contact. Proper personal protective equipment (PPE) such as gloves and masks is recommended during handling. Storage conditions are critical to maintain its stability; it should be kept in a cool, dry place away from light and moisture. Veterinary guidelines must be followed for dosage and administration to prevent adverse effects. Overdose can lead to gastrointestinal ulcers or renal damage in animals, so precise dosing is imperative. Always consult safety data sheets (SDS) for detailed handling instructions.
B2B Procurement Guide
When procuring Phenylbutazone Malate, B2B buyers should prioritize suppliers with certifications in veterinary pharmaceuticals. Verify the product's purity, solubility, and compliance with regulatory standards such as Good Manufacturing Practice (GMP). Price ranges vary depending on quantity and supplier, so obtaining multiple quotes is advisable. Bulk purchases may offer cost advantages, but ensure proper storage facilities are available. Always request certificates of analysis (CoA) to confirm the product meets specified quality criteria.
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